Design and Characterization of Hydroxyapatite Scaffolds Fabricated by Stereolithography for Bone Tissue Engineering Application

Zhen Wang, Chuanzhen Huang*, Jun Wang, Bin Zou, Ch Asad Abbas, Xiaodan Wang

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

25 Citations (Scopus)

Abstract

In this study, a novel method to design hydroxyapatite scaffold based on gradient porosity was proposed. Additionally, after a tailor-made ceramic suspension was cured by stereolithography (SLA), a minimal pore with a diameter size of 500μm can be fabricated, and it has a high dimension precision up to about 60μm. The compression test showed that the scaffolds had an effective elastic modulus ranging from 2.4GPa to 5.9GPa, which could match with the cancellous bone well. Moreover, in-vitro experiments demonstrated that this hydroxyapatite bioceramic scaffold was compatible with bone marrow mesenchymal stem cells (BMSCs) and showed good effect on cell proliferation.

Original languageEnglish
Pages (from-to)170-175
Number of pages6
JournalProcedia CIRP
Volume89
DOIs
Publication statusPublished - 2020
Externally publishedYes
Event4th CIRP Conference on Biomanufacturing, CIRP-BioM 2019 - Guangzhou, China
Duration: 12 Dec 201915 Dec 2019

Keywords

  • Bioceramic
  • Bone Scaffold
  • Gradient Porosity
  • Stereolithography

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