Decoding the role of zebrafish neuroglia in CNS disease modeling

Konstantin N. Zabegalov, Dongmei Wang, Long En Yang, Jingtao Wang, Guojun Hu, Nazar Serikuly, Erik T. Alpyshov, Sergey L. Khatsko, Aleksander Zhdanov, Konstantin A. Demin, David S. Galstyan, Andrey D. Volgin, Murilo S. de Abreu*, Tatyana Strekalova, Cai Song, Tamara G. Amstislavskaya, Yury Sysoev, Pavel E. Musienko, Allan V. Kalueff

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Neuroglia, including microglia and astrocytes, is a critical component of the central nervous system (CNS) that interacts with neurons to modulate brain activity, development, metabolism and signaling pathways. Thus, a better understanding of the role of neuroglia in the brain is critical. Complementing clinical and rodent data, the zebrafish (Danio rerio) is rapidly becoming an important model organism to probe the role of neuroglia in brain disorders. With high genetic and physiological similarity to humans and rodents, zebrafish possess some common (shared), as well as some specific molecular biomarkers and features of neuroglia development and functioning. Studying these common and zebrafish-specific aspects of neuroglia may generate important insights into key brain mechanisms, including neurodevelopmental, neurodegenerative, neuroregenerative and neurological processes. Here, we discuss the biology of neuroglia in humans, rodents and fish, its role in various CNS functions, and further directions of translational research into the role of neuroglia in CNS disorders using zebrafish models.

Original languageEnglish
Pages (from-to)44-53
Number of pages10
JournalBrain Research Bulletin
Publication statusPublished - Jan 2021
Externally publishedYes


  • CNS disorders
  • Macroglia
  • Microglia
  • Neuroglia
  • Rodents
  • Zebrafish


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