TY - JOUR
T1 - DARK Classics in Chemical Neuroscience
T2 - Kava
AU - Volgin, Andrey
AU - Yang, Longen
AU - Amstislavskaya, Tamara
AU - Demin, Konstantin
AU - Wang, Dongmei
AU - Yan, Dongni
AU - Wang, Jingtao
AU - Wang, Mengyao
AU - Alpyshov, Erik
AU - Hu, Guojun
AU - Serikuly, Nazar
AU - Shevyrin, Vadim
AU - Wappler-Guzzetta, Edina
AU - De Abreu, Murilo
AU - Kalueff, Allan
N1 - Publisher Copyright:
© 2020 American Chemical Society. All rights reserved.
PY - 2020/12/2
Y1 - 2020/12/2
N2 - Kava (kava kava, Piper methysticum) is a common drug-containing plant in the Pacific islands. Kavalactones, its psychoactive compounds, exert potent central nervous system (CNS) action clinically and in animal models. However, the exact pharmacological profiles and mechanisms of action of kava on the brain and behavior remain poorly understood. Here, we discuss clinical and experimental data on kava psychopharmacology and summarize chemistry and synthesis of kavalactones. We also review its societal impact, drug use and abuse potential, and future perspectives on translational kava research.
AB - Kava (kava kava, Piper methysticum) is a common drug-containing plant in the Pacific islands. Kavalactones, its psychoactive compounds, exert potent central nervous system (CNS) action clinically and in animal models. However, the exact pharmacological profiles and mechanisms of action of kava on the brain and behavior remain poorly understood. Here, we discuss clinical and experimental data on kava psychopharmacology and summarize chemistry and synthesis of kavalactones. We also review its societal impact, drug use and abuse potential, and future perspectives on translational kava research.
KW - anxiolysis
KW - kava
KW - kavalactones
KW - translational drug research
UR - http://www.scopus.com/inward/record.url?scp=85078892956&partnerID=8YFLogxK
U2 - 10.1021/acschemneuro.9b00587
DO - 10.1021/acschemneuro.9b00587
M3 - Review article
C2 - 31904216
AN - SCOPUS:85078892956
SN - 1948-7193
VL - 11
SP - 3893
EP - 3904
JO - ACS Chemical Neuroscience
JF - ACS Chemical Neuroscience
IS - 23
ER -