Cytokine and endocrine parameters in mouse chronic social defeat: Implications for translational 'cross-domain' modeling of stress-related brain disorders

Adam Michael Stewart, Sudipta Roy, Keith Wong, Siddharth Gaikwad, Kyung Min Chung, Allan V. Kalueff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Mounting clinical and experimental evidence implicates various cytokines in stress-related affective brain disorders. Here, we analyze behavioral phenotypes in C57BL/6J male mice following the chronic social defeat stress paradigm, and examine their serum cytokines and corticosterone levels. Loser mice experiencing 20 days of daily 15-min social confrontations demonstrate elevated levels of pro-inflammatory cytokines interleukin IL-7 and vascular endothelial growth factor (VEGF), as well as a trend to increase IL-6 and IL-15. We also found higher levels of an anti-inflammatory cytokine IL-10 in the winner mice, with unaltered serum IL-2, IL-4, IL-1a, MCP-1 and corticosterone levels between the groups. Overall, our results suggest that animal affective-like states correlate with specific cytokine profiles, including some cytokines (e.g., VEGF, IL-7 or IL-15) whose role in neuropsychiatric disorders is only beginning to emerge. This study emphasizes the importance of integrative analyses of neural and immune phenotypes in stress and stress-related neurobehavioral disorders. These findings may also help foster the search for new therapeutic and preventative strategies that target selected cytokines and their signaling pathways.

Original languageEnglish
Pages (from-to)84-91
Number of pages8
JournalBehavioural Brain Research
Volume276
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Anxiety
  • Corticosterone
  • Cytokine
  • Mice
  • Social defeat
  • Stress

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