Cultrue-independent digging of cellulases and genes from natural environments

Yongtao Zhu, Weifeng Liu*, Lushan Wang, Guanjun Chen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


There is a great diversity for cellulolytic microbes in nature and the strategies they use to digest cellulose. In addition to the cultured cellulolytic microbes, there are still a great number of microbes being not readily culturable in natural environments, which may represent great potential for identifying novel cellulases and their encoding genes. The rise of metagenomics and metaproteomics provides essential technologic tools to dig up these resources and significant progress has been made so far. This review gives an insight into some relative results that have arisen from the meta-genomic or proteomic analysis of definitive uncultured microbe communities. Their potential role in elucidating the process and mechanisms of cellulose degradation in natural environment from the point of "community system microbiology" is also discussed.

Original languageEnglish
Pages (from-to)1838-1843
Number of pages6
JournalShengwu Gongcheng Xuebao/Chinese Journal of Biotechnology
Issue number12
Publication statusPublished - 2009
Externally publishedYes


  • Cellulases
  • Cellulose
  • Metagenomics
  • Metaproteomics
  • System biology


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