TY - JOUR
T1 - Coronavirus disease 2019 in pregnancy
AU - the sixth batch of Anhui medical team aiding Wuhan for COVID-19
AU - Qiancheng, Xu
AU - Jian, Shen
AU - Lingling, Pan
AU - Lei, Huang
AU - Xiaogan, Jiang
AU - Weihua, Lu
AU - Gang, Yang
AU - Shirong, Li
AU - Zhen, Wang
AU - GuoPing, Xiong
AU - Lei, Zha
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020/6
Y1 - 2020/6
N2 - Objectives: This study aimed to compare clinical courses and outcomes between pregnant and reproductive-aged non-pregnant women with COVID-19, and to assess the vertical transmission potential of COVID-19 in pregnancy. Methods: Medical records of pregnant and reproductive-aged non-pregnant women hospitalized with COVID-19 from January 15 to March 15, 2020 were retrospectively reviewed. The severity of disease, virus clearance time, and length of hospital stay were measured as the primary objective, while the vertical transmission potential of COVID-19 was also assessed. Results: Eighty-two patients (28 pregnant women, 54 reproductive-aged non-pregnant women) with laboratory-confirmed COVID-19 were enrolled in this study. Univariate regression indicated no association between pregnancy and severity of disease (OR 0.73, 95% CI 0.08–5.15; p = 0.76), virus clearance time (HR 1.16, 95% CI 0.65–2.01; p = 0.62), and length of hospital stay (HR 1.10, 95% CI 0.66–1.84; p = 0.71). Of the pregnant women, 22 delivered 23 live births, either by cesarean section (17, 60.7%) or vaginal delivery (5, 17.9%), and no neonate was infected with SARS-CoV-2. Conclusions: Pregnant women have comparable clinical courses and outcomes with reproductive-aged non-pregnant women when infected with SARS-CoV-2. No evidence supported vertical transmission of COVID-19 in the late stage of pregnancy, including vaginal delivery.
AB - Objectives: This study aimed to compare clinical courses and outcomes between pregnant and reproductive-aged non-pregnant women with COVID-19, and to assess the vertical transmission potential of COVID-19 in pregnancy. Methods: Medical records of pregnant and reproductive-aged non-pregnant women hospitalized with COVID-19 from January 15 to March 15, 2020 were retrospectively reviewed. The severity of disease, virus clearance time, and length of hospital stay were measured as the primary objective, while the vertical transmission potential of COVID-19 was also assessed. Results: Eighty-two patients (28 pregnant women, 54 reproductive-aged non-pregnant women) with laboratory-confirmed COVID-19 were enrolled in this study. Univariate regression indicated no association between pregnancy and severity of disease (OR 0.73, 95% CI 0.08–5.15; p = 0.76), virus clearance time (HR 1.16, 95% CI 0.65–2.01; p = 0.62), and length of hospital stay (HR 1.10, 95% CI 0.66–1.84; p = 0.71). Of the pregnant women, 22 delivered 23 live births, either by cesarean section (17, 60.7%) or vaginal delivery (5, 17.9%), and no neonate was infected with SARS-CoV-2. Conclusions: Pregnant women have comparable clinical courses and outcomes with reproductive-aged non-pregnant women when infected with SARS-CoV-2. No evidence supported vertical transmission of COVID-19 in the late stage of pregnancy, including vaginal delivery.
KW - clinical feature
KW - COVID-19
KW - infection
KW - pregnancy
KW - SARS-CoV-2
KW - virus
UR - http://www.scopus.com/inward/record.url?scp=85084617459&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2020.04.065
DO - 10.1016/j.ijid.2020.04.065
M3 - Article
C2 - 32353549
AN - SCOPUS:85084617459
SN - 1201-9712
VL - 95
SP - 376
EP - 383
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -