Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet(X3) and tet(X4) in Dairy Cows on a Chinese Farm

Rong Zhang, Ning Dong, Yu Zeng, Zhangqi Shen, Jiayue Lu, Congcong Liu, Zhuo An Huang, Qiaoling Sun, Qipeng Cheng, Lingbin Shu, Jiachang Cai, Edward Waichi Chan, Dejun Liu, Gongxiang Chen, Yang Wang*, Sheng Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

We isolated 47 Acinetobacter strains carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows on a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBΚ/FIA(HI1)/X1 nontransferable plasmid. The coexistence of tet(X3) and carbapenemase genes, including blaOXA-58 and blaNDM-1, was detected in 9 Acinetobacter spp. These findings suggested that the use of tetracycline and other antibiotics in food production warrants urgent attention.

Original languageEnglish
Article numbere00674
JournalAntimicrobial Agents and Chemotherapy
Volume64
Issue number11
DOIs
Publication statusPublished - Oct 2020
Externally publishedYes

Keywords

  • Acinetobacter spp
  • Dairy cow
  • E. coli
  • Epidemiology
  • GI tract
  • Tet(X3)
  • Tet(X4)
  • Tigecycline
  • WGS

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