Mechanism of action of antiepileptic drugs

Haider Ali, Naushad Ahmad Khan, Mirza Masroor Ali Beg, Mohammed Zahed Sarwar, Nurida Kemelbek Kyzy, Tilekeeva Ulankul Muktarovna, Kudaibergen Osmonaliev, Faez Iqbal Khan, Muhammed Burak Ay

Research output: Chapter in Book or Report/Conference proceedingChapterpeer-review


About 1% of the general population suffers from epilepsy, which may leave them severely handicapped. Antiepileptic medications have a major role in the treatment of seizures in people with epilepsy (AEDs). Some of the most common drugs used to treat epilepsy have included phenobarbital, carbamazepine, valproic acid, and phenytoin. There are many AEDs licensed by the FDA since 1993 for use in the treatment of epilepsy. The kind of seizure, clinical activity range, side effect profile, and patient variables such as age, comorbidities, and concomitant medical therapies all factor into the decision to use an AED. It is common for AEDs with broad-spectrum efficacy to have many molecular targets. This chapter will examine the potential mechanisms of action of commercialized AEDs in the United States and evaluate the future of AEDs under development.

Original languageEnglish
Title of host publicationHow Synthetic Drugs Work
Subtitle of host publicationInsights into Molecular Pharmacology of Classic and New Pharmaceuticals
Number of pages17
ISBN (Electronic)9780323998550
ISBN (Print)9780323913683
Publication statusPublished - 1 Jan 2023


  • anticonvulsant drugs
  • epilepsy
  • mechanism of action
  • seizures


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