Cell-type-based model explaining coexpression patterns of genes in the brain

Pascal Grange*, Jason W. Bohland, Benjamin W. Okaty, Ken Sugino, Hemant Bokil, Sacha B. Nelson, Lydia Ng, Michael Hawrylycz, Partha P. Mitra

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Spatial patterns of gene expression in the vertebrate brain are not independent, as pairs of genes can exhibit complex patterns of coexpression. Two genes may be similarly expressed in one region, but differentially expressed in other regions. These correlations have been studied quantitatively, particularly for the Allen Atlas of the adult mouse brain, but their biological meaning remains obscure. We propose a simple model of the coexpression patterns in terms of spatial distributions of underlying cell types and establish its plausibility using independently measured cell-type- specific transcriptomes. The model allows us to predict the spatial distribution of cell types in the mouse brain.

Original languageEnglish
Pages (from-to)5397-5402
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number14
Publication statusPublished - 2014


  • Bioinformatics
  • Neuroanatomy
  • Neuroscience

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