Ca 2+ signaling and spinocerebellar ataxia

Chihiro Hisatsune*, Kozo Hamada, Katsuhiko Mikoshiba

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


Spinocerebellar ataxia (SCA) is a neural disorder, which is caused by degenerative changes in the cerebellum. SCA is primarily characterized by gait ataxia, and additional clinical features include nystagmus, dysarthria, tremors and cerebellar atrophy. Forty-four hereditary SCAs have been identified to date, along with >35 SCA-associated genes. Despite the great diversity and distinct functionalities of the SCA-related genes, accumulating evidence supports the occurrence of a common pathophysiological event among several hereditary SCAs. Altered calcium (Ca 2+ ) homeostasis in the Purkinje cells (PCs) of the cerebellum has been proposed as a possible pathological SCA trigger. In support of this, signaling events that are initiated from or lead to aberrant Ca 2+ release from the type 1 inositol 1,4,5-trisphosphate receptor (IP 3 R1), which is highly expressed in cerebellar PCs, seem to be closely associated with the pathogenesis of several SCA types. In this review, we summarize the current research on pathological hereditary SCA events, which involve altered Ca 2+ homeostasis in PCs, through IP 3 R1 signaling.

Original languageEnglish
Pages (from-to)1733-1744
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Issue number11
Publication statusPublished - Nov 2018
Externally publishedYes


  • Calcium
  • Cerebellum
  • Endoplasmic reticulum
  • IP receptor


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