Behavioral effects of MDMA ('ecstasy') on adult zebrafish

Adam Stewart; Russell Riehl; Keith Wong; Jeremy Green; Jessica Cosgrove; Karoly Vollmer; Evan Kyzar; Peter Hart; Alexander Allain; Jonathan Cachat; Siddharth Gaikwad; Molly Hook; Kate Rhymes; Alan Newman; Eli Utterback; Katie Chang; Allan V. Kalueff

doi:10.1097/FBP.0b013e328345f758

Behavioral effects of MDMA ('ecstasy') on adult zebrafish

Adam Stewart, Russell Riehl, Keith Wong, Jeremy Green, Jessica Cosgrove, Karoly Vollmer, Evan Kyzar, Peter Hart, Alexander Allain, Jonathan Cachat, Siddharth Gaikwad, Molly Hook, Kate Rhymes, Alan Newman, Eli Utterback, Katie Chang, Allan V. Kalueff

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a potent psychedelic drug inducing euphoria and hypersociability in humans, as well as hyperactivity and anxiety in rodents. Adult zebrafish (Danio rerio) have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/l) of acute MDMA doses on zebrafish behavior in the novel tank test. Although MDMA was inactive at lower doses (0.25-10 mg/l), higher doses reduced bottom swimming and immobility (40-120 mg/l) and impaired intrasession habituation (10-120 mg/l). MDMA also elevated brain c-fos expression, collectively confirming the usage of zebrafish models for screening of hallucinogenic compounds.

Original language	English
Pages (from-to)	275-280
Number of pages	6
Journal	Behavioural Pharmacology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1097/FBP.0b013e328345f758
Publication status	Published - Jun 2011
Externally published	Yes

Keywords

3,4-methylenedioxymethamphetamine
anxiety
locomotion
novelty-based paradigms
psychedelic hallucinogenic drugs
zebrafish

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/FBP.0b013e328345f758

Cite this

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title = "Behavioral effects of MDMA ('ecstasy') on adult zebrafish",

abstract = "3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a potent psychedelic drug inducing euphoria and hypersociability in humans, as well as hyperactivity and anxiety in rodents. Adult zebrafish (Danio rerio) have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/l) of acute MDMA doses on zebrafish behavior in the novel tank test. Although MDMA was inactive at lower doses (0.25-10 mg/l), higher doses reduced bottom swimming and immobility (40-120 mg/l) and impaired intrasession habituation (10-120 mg/l). MDMA also elevated brain c-fos expression, collectively confirming the usage of zebrafish models for screening of hallucinogenic compounds.",

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author = "Adam Stewart and Russell Riehl and Keith Wong and Jeremy Green and Jessica Cosgrove and Karoly Vollmer and Evan Kyzar and Peter Hart and Alexander Allain and Jonathan Cachat and Siddharth Gaikwad and Molly Hook and Kate Rhymes and Alan Newman and Eli Utterback and Katie Chang and Kalueff, {Allan V.}",

year = "2011",

month = jun,

doi = "10.1097/FBP.0b013e328345f758",

language = "English",

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AU - Stewart, Adam

AU - Riehl, Russell

AU - Wong, Keith

AU - Green, Jeremy

AU - Cosgrove, Jessica

AU - Vollmer, Karoly

AU - Kyzar, Evan

AU - Hart, Peter

AU - Allain, Alexander

AU - Cachat, Jonathan

AU - Gaikwad, Siddharth

AU - Hook, Molly

AU - Rhymes, Kate

AU - Newman, Alan

AU - Utterback, Eli

AU - Chang, Katie

AU - Kalueff, Allan V.

PY - 2011/6

Y1 - 2011/6

N2 - 3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a potent psychedelic drug inducing euphoria and hypersociability in humans, as well as hyperactivity and anxiety in rodents. Adult zebrafish (Danio rerio) have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/l) of acute MDMA doses on zebrafish behavior in the novel tank test. Although MDMA was inactive at lower doses (0.25-10 mg/l), higher doses reduced bottom swimming and immobility (40-120 mg/l) and impaired intrasession habituation (10-120 mg/l). MDMA also elevated brain c-fos expression, collectively confirming the usage of zebrafish models for screening of hallucinogenic compounds.

AB - 3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a potent psychedelic drug inducing euphoria and hypersociability in humans, as well as hyperactivity and anxiety in rodents. Adult zebrafish (Danio rerio) have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/l) of acute MDMA doses on zebrafish behavior in the novel tank test. Although MDMA was inactive at lower doses (0.25-10 mg/l), higher doses reduced bottom swimming and immobility (40-120 mg/l) and impaired intrasession habituation (10-120 mg/l). MDMA also elevated brain c-fos expression, collectively confirming the usage of zebrafish models for screening of hallucinogenic compounds.

KW - 3,4-methylenedioxymethamphetamine

KW - anxiety

KW - locomotion

KW - novelty-based paradigms

KW - psychedelic hallucinogenic drugs

KW - zebrafish

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SN - 0955-8810

VL - 22

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EP - 280

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

IS - 3

ER -

Behavioral effects of MDMA ('ecstasy') on adult zebrafish

Abstract

Keywords

UN SDGs

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