Antiulcerogenic effects of benzylpenicillin in acutely stressed rats

A. V. Kaluev*, G. E. Samonina, I. P. Ashmarin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The antibiotic benzylpenicillin was found to produce dose-dependent antiulcerogenic effects in rats when administered immediately before their exposure to acute stress (swimming for 1 h) that led to gastric mucosal ulceration. Such effects were not observed in rats given benzylpenicillin 48 h before stress exposure. The results of this study suggest that in acutely stressed animals benzylpenicillin may activate as yet unidentified mechanisms which afford protection to the gastric mucosa and which are not associated with the longer-lasting antimicrobial effects of this antibiotic.

Original languageEnglish
Pages (from-to)818-820
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Issue number2
Publication statusPublished - Aug 1994
Externally publishedYes


  • acute stress
  • benzylpenicillin
  • ulcerogenesis


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