Anthocyanins: Multi-target agents for prevention and therapy of chronic diseases

Swathi Putta, Nagendra S. Yarla*, Ilaria Peluso, Dinesh K. Tiwari, Gorlav Reddy, Priyanka V. Giri, Naresh Kumar, Ramarao Malla, Vijaya Rachel, P. Veera Bramhachari, Rama S.D. Reddy, Ramesh Bade, Mastan Mannarapu, George E. Barreto, Da Yong Lu, Vadim V. Tarasov, Vladimir N. Chubarev, Frederico F. Ribeiro, Luciana Scotti, Marcus T. ScottiM. A. Kamal, Ghulam Md Ashraf, Gjumrakch Aliev, George Perry, Satyajit D. Sarker, Chinthalapally V. Rao, Anupam Bishayee

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

Anthocyanins, a flavonoid class of polyphenols, are water soluble dark colored natural pigments found in fruits and vegetables. Owing to their wide distribution in plant materials, dietary consumption of anthocyanins is high compared to other flavonoids. Anthocyanins, due to their multifaceted medicinal properties are the active components in many herbal folk medicines. As in vitro and in vivo results, animal models, and clinical trials in various cell lines suggest, anthocyanins possess antioxidant, antidiabetic, antihyperlipidemic, anti-inflammatory, anticarcinogenic, antiulcer, and preventive activities against cardiovascular diseases. Additionally, anthocyanins exhibit chemotherapeutic, cardioprotective, hepatoprotective, and neuroprotective activities. In the diet, anthocyanins are absorbed in the stomach and intestinal cells and rapidly detected in the plasma. These promising properties of anthocyanins may well provide health benefits against chronic diseases.

Original languageEnglish
Pages (from-to)6321-6346
Number of pages26
JournalCurrent Pharmaceutical Design
Volume23
Issue number41
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Anthocyanins
  • Anti-inflammatory and anticarcinogenic activity
  • Antidiabetic
  • Antihyperlipidemic
  • Antioxidant
  • Multitarget therapeutic agents

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