1 Citation (Scopus)

Abstract

Mounting evidence links psychiatric disorders to central and systemic inflammation. Experimental (animal) models of psychiatric disorders are important tools for translational biopsychiatry research and CNS drug discovery. Current experimental models, most typically involving rodents, continue to reveal shared fundamental pathological pathways and biomarkers underlying the pathogenetic link between brain illnesses and neuroinflammation. Recent data also show that various proinflammatory factors can alter brain neurochemistry, modulating the levels of neurohormones and neurotrophins in neurons and microglia. The role of “active” glia in releasing a wide range of proinflammatory cytokines also implicates glial cells in various psychiatric disorders. Here, we discuss recent animal inflammation-related models of psychiatric disorders, focusing on their translational perspectives and the use of some novel promising model organisms (zebrafish), to better understand the evolutionally conservative role of inflammation in neuropsychiatric conditions.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages91-104
Number of pages14
DOIs
Publication statusPublished - 2023
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1411
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Animal models
  • Model organisms
  • Neurodegeneration
  • Neuroinflammation
  • Rodents
  • Zebrafish

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