Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein

Ming ming Xu*, Philip Ryan, Santosh Rudrawar, Ronald J. Quinn, Hai yan Zhang, George D. Mellick

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)

Abstract

Abnormal protein aggregation has been linked to many neurodegenerative diseases, including Parkinson’s disease (PD). The main pathological hallmark of PD is the formation of Lewy bodies (LBs) and Lewy neurites, both of which contain the presynaptic protein alpha-synuclein (α-syn). Under normal conditions, native α-syn exists in a soluble unfolded state but undergoes misfolding and aggregation into toxic aggregates under pathological conditions. Toxic α-syn species, especially oligomers, can cause oxidative stress, membrane penetration, synaptic and mitochondrial dysfunction, as well as other damage, leading to neuronal death and eventually neurodegeneration. Early diagnosis and treatments targeting PD pathogenesis are urgently needed. Given its critical role in PD, α-syn is an attractive target for the development of both diagnostic tools and effective therapeutics. This review summarizes the progress toward discovering imaging probes and aggregation inhibitors for α-syn. Relevant strategies and techniques in the discovery of α-syn-targeted drugs are also discussed.

Original languageEnglish
Pages (from-to)483-498
Number of pages16
JournalActa Pharmacologica Sinica
Volume41
Issue number4
DOIs
Publication statusPublished - 1 Apr 2020
Externally publishedYes

Keywords

  • Parkinson’s disease
  • aggregation inhibitors
  • alpha-synuclein
  • imaging probes
  • mass spectrometry
  • thioflavin-T

Fingerprint

Dive into the research topics of 'Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein'. Together they form a unique fingerprint.

Cite this