TY - JOUR
T1 - Aberrantly regulated proteins in frontotemporal dementia
AU - Schweitzer, Kelly
AU - Decker, Emily
AU - Zhu, Liping
AU - Miller, Richard E.
AU - Mirra, Suzanne S.
AU - Spina, Salvatore
AU - Ghetti, Bernardino
AU - Wang, Mu
AU - Murrell, Jill
N1 - Funding Information:
This research was supported by Public Health Service Grants RO1 NS37431 and P30 AG10133.
PY - 2006/9/22
Y1 - 2006/9/22
N2 - Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.
AB - Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.
KW - Frontotemporal dementia and parkinsonism linked to chromosome 17
KW - Matrix-assisted laser desorption/ionization time-of-flight
KW - Oxidative stress
KW - Two-dimensional electrophoresis
KW - UCHL1
KW - Ubiquitin C-terminal hydrolyase L1
UR - http://www.scopus.com/inward/record.url?scp=33746921194&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2006.07.113
DO - 10.1016/j.bbrc.2006.07.113
M3 - Article
C2 - 16890190
AN - SCOPUS:33746921194
SN - 0006-291X
VL - 348
SP - 465
EP - 472
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -
