TY - GEN
T1 - A simulation of synthetic agr system in E.coli
AU - Zeng, Xiangmiao
AU - Liu, Ke
AU - Xie, Fangping
AU - Zhang, Ying
AU - Qiao, Lei
AU - Dai, Cuihong
AU - Hou, Aiju
AU - Xu, Dechang
PY - 2013
Y1 - 2013
N2 - Staphylococcus aureus (S.aureus) is an important human pathogen. Its strong infection ability benefits from the quorum-sensing system agr (accessory gene regulator). In order to eliminate S.aureus from the environment, an engineered E.coli was designed. It can sense the extracellular AIP (auto-inducing peptide) and then, as a response, produce Lysostaphin to kill S.aureus. To characterizing how E.coli sense S.aureus and secrete Lysostaphin, a mathematical model was developed. According to the model, it is at least 2.5 hours for the system to sense the AIP (S.aureus) and then produce enough Lysostaphin to kill the S.aureus, and therefore keep the AIP concentration at a relative low condition.
AB - Staphylococcus aureus (S.aureus) is an important human pathogen. Its strong infection ability benefits from the quorum-sensing system agr (accessory gene regulator). In order to eliminate S.aureus from the environment, an engineered E.coli was designed. It can sense the extracellular AIP (auto-inducing peptide) and then, as a response, produce Lysostaphin to kill S.aureus. To characterizing how E.coli sense S.aureus and secrete Lysostaphin, a mathematical model was developed. According to the model, it is at least 2.5 hours for the system to sense the AIP (S.aureus) and then produce enough Lysostaphin to kill the S.aureus, and therefore keep the AIP concentration at a relative low condition.
KW - agr
KW - E.coli
KW - quorum-sensing system
KW - S.aureus
KW - simulation
UR - http://www.scopus.com/inward/record.url?scp=84883324438&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-38036-5_11
DO - 10.1007/978-3-642-38036-5_11
M3 - Conference Proceeding
AN - SCOPUS:84883324438
SN - 9783642380358
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 76
EP - 86
BT - Bioinformatics Research and Applications - 9th International Symposium, ISBRA 2013, Proceedings
T2 - 9th International Symposium on Bioinformatics Research and Applications, ISBRA 2013
Y2 - 20 May 2013 through 22 May 2013
ER -