A simulation of synthetic agr system in E.coli

Xiangmiao Zeng, Ke Liu, Fangping Xie, Ying Zhang, Lei Qiao, Cuihong Dai, Aiju Hou, Dechang Xu

Research output: Chapter in Book or Report/Conference proceedingConference Proceedingpeer-review


Staphylococcus aureus (S.aureus) is an important human pathogen. Its strong infection ability benefits from the quorum-sensing system agr (accessory gene regulator). In order to eliminate S.aureus from the environment, an engineered E.coli was designed. It can sense the extracellular AIP (auto-inducing peptide) and then, as a response, produce Lysostaphin to kill S.aureus. To characterizing how E.coli sense S.aureus and secrete Lysostaphin, a mathematical model was developed. According to the model, it is at least 2.5 hours for the system to sense the AIP (S.aureus) and then produce enough Lysostaphin to kill the S.aureus, and therefore keep the AIP concentration at a relative low condition.

Original languageEnglish
Title of host publicationBioinformatics Research and Applications - 9th International Symposium, ISBRA 2013, Proceedings
Number of pages11
Publication statusPublished - 2013
Externally publishedYes
Event9th International Symposium on Bioinformatics Research and Applications, ISBRA 2013 - Charlotte, NC, United States
Duration: 20 May 201322 May 2013

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7875 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference9th International Symposium on Bioinformatics Research and Applications, ISBRA 2013
Country/TerritoryUnited States
CityCharlotte, NC


  • agr
  • E.coli
  • quorum-sensing system
  • S.aureus
  • simulation


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