TY - GEN
T1 - A novel method to estimate baroreflex sensitivity based on pulse transit time
AU - Liu, Qing
AU - Carmen,
AU - Poon, C. Y.
AU - Zhang, Yuan Ting
PY - 2012
Y1 - 2012
N2 - Baroreflex sensitivity (BRS) has emerged as a prognostic factor in cardiology. Spontaneous sequence technique is one of the most commonly used methods in measuring BRS. The technique requires continuous beat-to-beat blood pressure (BP) which, however, cannot be obtained conveniently. Considering that pulse transit time (PTT) is inversely related to BP and can be easily and continuously acquired from electrocardiogram (ECG) and photoplethysmogram (PPG), we proposed in this study a novel method that estimates BRS from PTT based on the sequence technique with low-pass filtering. The experiment was conducted on 25 healthy subjects from whom continuous BP, PTT and R-R interval (RRI) of ECG were obtained before, during and after drinking 400ml of water. SBP-based BRS and PTT-based BRS were separately calculated. The results showed high correlations between these two BRS estimates in all situations (correlation coefficient γ=0.90, 0.70 and 0.81 before, during and after drinking respectively). Furthermore, results from both methods indicate that BRS increased significantly (p<0.01) after water drinking.
AB - Baroreflex sensitivity (BRS) has emerged as a prognostic factor in cardiology. Spontaneous sequence technique is one of the most commonly used methods in measuring BRS. The technique requires continuous beat-to-beat blood pressure (BP) which, however, cannot be obtained conveniently. Considering that pulse transit time (PTT) is inversely related to BP and can be easily and continuously acquired from electrocardiogram (ECG) and photoplethysmogram (PPG), we proposed in this study a novel method that estimates BRS from PTT based on the sequence technique with low-pass filtering. The experiment was conducted on 25 healthy subjects from whom continuous BP, PTT and R-R interval (RRI) of ECG were obtained before, during and after drinking 400ml of water. SBP-based BRS and PTT-based BRS were separately calculated. The results showed high correlations between these two BRS estimates in all situations (correlation coefficient γ=0.90, 0.70 and 0.81 before, during and after drinking respectively). Furthermore, results from both methods indicate that BRS increased significantly (p<0.01) after water drinking.
UR - http://www.scopus.com/inward/record.url?scp=84864275569&partnerID=8YFLogxK
U2 - 10.1109/BHI.2012.6211608
DO - 10.1109/BHI.2012.6211608
M3 - Conference Proceeding
AN - SCOPUS:84864275569
SN - 9781457721779
T3 - Proceedings - IEEE-EMBS International Conference on Biomedical and Health Informatics: Global Grand Challenge of Health Informatics, BHI 2012
SP - 432
EP - 434
BT - Proceedings - IEEE-EMBS International Conference on Biomedical and Health Informatics
T2 - IEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on Biomedical and Health Engineering
Y2 - 2 January 2012 through 7 January 2012
ER -