A new type of cuprous-cysteamine sensitizers: Synthesis, optical properties and potential applications

Y. Wang; N. D. Alkhaldi; N. K. Pandey; L. Chudal; L. Y. Wang; L. W. Lin; M. B. Zhang; Y. X. Yong; E. H. Amador; M. N. Huda; W. Chen

doi:10.1016/j.mtphys.2021.100435

A new type of cuprous-cysteamine sensitizers: Synthesis, optical properties and potential applications

Y. Wang, N. D. Alkhaldi, N. K. Pandey, L. Chudal, L. Y. Wang, L. W. Lin, M. B. Zhang^*, Y. X. Yong, E. H. Amador, M. N. Huda^*, W. Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Herein, for the first time, we report a series of cuprous-cysteamine (Cu-Cy-X, X = F, Cl, Br, and I)) sensitizers that possess tunable fluorescence from orange to yellow. The Cu-Cy-X can generate reactive oxygen species (ROS), including singlet oxygen (¹O₂) in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F under UV and microwave excitation. Further study revealed that Cu-Cy-X has stability in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F. In this work, a detailed synthesis technique, crystal structure, optical properties, and mechanism of the observed trend in ¹O₂ generation, luminescence spectra, and anticancer effect are discussed in both theoretical and experimental points of view. These new materials will open a new door for photodynamic therapy and many other potential applications such as sensing, lighting, displays, labeling, and medical imaging.

Original language	English
Article number	100435
Journal	Materials Today Physics
Volume	19
DOIs	https://doi.org/10.1016/j.mtphys.2021.100435
Publication status	Published - Jul 2021
Externally published	Yes

Keywords

Cuprous-cysteamine
Density functional theory (DFT)
Luminescence
Microwave
Photodynamic therapy
Reactive oxygen species
Sensitizer
Singlet oxygen

Access to Document

10.1016/j.mtphys.2021.100435

Cite this

@article{496e4d37b0ba44dea7213fabdf2df809,

title = "A new type of cuprous-cysteamine sensitizers: Synthesis, optical properties and potential applications",

abstract = "Herein, for the first time, we report a series of cuprous-cysteamine (Cu-Cy-X, X = F, Cl, Br, and I)) sensitizers that possess tunable fluorescence from orange to yellow. The Cu-Cy-X can generate reactive oxygen species (ROS), including singlet oxygen (1O2) in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F under UV and microwave excitation. Further study revealed that Cu-Cy-X has stability in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F. In this work, a detailed synthesis technique, crystal structure, optical properties, and mechanism of the observed trend in 1O2 generation, luminescence spectra, and anticancer effect are discussed in both theoretical and experimental points of view. These new materials will open a new door for photodynamic therapy and many other potential applications such as sensing, lighting, displays, labeling, and medical imaging.",

keywords = "Cuprous-cysteamine, Density functional theory (DFT), Luminescence, Microwave, Photodynamic therapy, Reactive oxygen species, Sensitizer, Singlet oxygen",

author = "Y. Wang and Alkhaldi, {N. D.} and Pandey, {N. K.} and L. Chudal and Wang, {L. Y.} and Lin, {L. W.} and Zhang, {M. B.} and Yong, {Y. X.} and Amador, {E. H.} and Huda, {M. N.} and W. Chen",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = jul,

doi = "10.1016/j.mtphys.2021.100435",

language = "English",

volume = "19",

journal = "Materials Today Physics",

issn = "2542-5293",

}

TY - JOUR

T1 - A new type of cuprous-cysteamine sensitizers

T2 - Synthesis, optical properties and potential applications

AU - Wang, Y.

AU - Alkhaldi, N. D.

AU - Pandey, N. K.

AU - Chudal, L.

AU - Wang, L. Y.

AU - Lin, L. W.

AU - Zhang, M. B.

AU - Yong, Y. X.

AU - Amador, E. H.

AU - Huda, M. N.

AU - Chen, W.

PY - 2021/7

Y1 - 2021/7

N2 - Herein, for the first time, we report a series of cuprous-cysteamine (Cu-Cy-X, X = F, Cl, Br, and I)) sensitizers that possess tunable fluorescence from orange to yellow. The Cu-Cy-X can generate reactive oxygen species (ROS), including singlet oxygen (1O2) in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F under UV and microwave excitation. Further study revealed that Cu-Cy-X has stability in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F. In this work, a detailed synthesis technique, crystal structure, optical properties, and mechanism of the observed trend in 1O2 generation, luminescence spectra, and anticancer effect are discussed in both theoretical and experimental points of view. These new materials will open a new door for photodynamic therapy and many other potential applications such as sensing, lighting, displays, labeling, and medical imaging.

AB - Herein, for the first time, we report a series of cuprous-cysteamine (Cu-Cy-X, X = F, Cl, Br, and I)) sensitizers that possess tunable fluorescence from orange to yellow. The Cu-Cy-X can generate reactive oxygen species (ROS), including singlet oxygen (1O2) in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F under UV and microwave excitation. Further study revealed that Cu-Cy-X has stability in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F. In this work, a detailed synthesis technique, crystal structure, optical properties, and mechanism of the observed trend in 1O2 generation, luminescence spectra, and anticancer effect are discussed in both theoretical and experimental points of view. These new materials will open a new door for photodynamic therapy and many other potential applications such as sensing, lighting, displays, labeling, and medical imaging.

KW - Cuprous-cysteamine

KW - Density functional theory (DFT)

KW - Luminescence

KW - Microwave

KW - Photodynamic therapy

KW - Reactive oxygen species

KW - Sensitizer

KW - Singlet oxygen

UR - http://www.scopus.com/inward/record.url?scp=85106925346&partnerID=8YFLogxK

U2 - 10.1016/j.mtphys.2021.100435

DO - 10.1016/j.mtphys.2021.100435

M3 - Article

AN - SCOPUS:85106925346

SN - 2542-5293

VL - 19

JO - Materials Today Physics

JF - Materials Today Physics

M1 - 100435

ER -

A new type of cuprous-cysteamine sensitizers: Synthesis, optical properties and potential applications

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this