A functional model of cytochrome c oxidase: Thermodynamic implications

James P. Collman; Lei Fu; Paul C. Herrmann; Zhong Wang; Miroslav Rapta; Martin Bröring; Reinhold Schwenninger; Bernard Boitrel

doi:10.1002/(SICI)1521-3773(19981231)37:24<3397::AID-ANIE3397>3.0.CO;2-N

A functional model of cytochrome c oxidase: Thermodynamic implications

James P. Collman^*, Lei Fu, Paul C. Herrmann, Zhong Wang, Miroslav Rapta, Martin Bröring, Reinhold Schwenninger, Bernard Boitrel

^*Corresponding author for this work

Stanford University

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

The environment of the Cu(I) ion in the distal ligand group decides the fate of the reduction of O₂ by the two analogues 1 and 2 of the heme a₃Cu(B) center in cytochrome c oxidase. The fourfold coordination by N in 1 favors the Cu(II) oxidation state and leads to a 4e^--4H⁺ reduction and the formation of H₂O under physiological conditions, while with 2 a 2e^--2H⁺ reduction occurs to form the cytotoxic H₂O₂.

Original language	English
Pages (from-to)	3397-3400
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	37
Issue number	24
DOIs	https://doi.org/10.1002/(SICI)1521-3773(19981231)37:24<3397::AID-ANIE3397>3.0.CO;2-N
Publication status	Published - 4 Jan 1999
Externally published	Yes

Keywords

Cytochrome c oxidase
Electrochemistry
Heme proteins
N ligands
O-O activation

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10.1002/(SICI)1521-3773(19981231)37:24<3397::AID-ANIE3397>3.0.CO;2-N

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AU - Collman, James P.

AU - Fu, Lei

AU - Herrmann, Paul C.

AU - Wang, Zhong

AU - Rapta, Miroslav

AU - Bröring, Martin

AU - Schwenninger, Reinhold

AU - Boitrel, Bernard

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N2 - The environment of the Cu(I) ion in the distal ligand group decides the fate of the reduction of O2 by the two analogues 1 and 2 of the heme a3Cu(B) center in cytochrome c oxidase. The fourfold coordination by N in 1 favors the Cu(II) oxidation state and leads to a 4e--4H+ reduction and the formation of H2O under physiological conditions, while with 2 a 2e--2H+ reduction occurs to form the cytotoxic H2O2.

AB - The environment of the Cu(I) ion in the distal ligand group decides the fate of the reduction of O2 by the two analogues 1 and 2 of the heme a3Cu(B) center in cytochrome c oxidase. The fourfold coordination by N in 1 favors the Cu(II) oxidation state and leads to a 4e--4H+ reduction and the formation of H2O under physiological conditions, while with 2 a 2e--2H+ reduction occurs to form the cytotoxic H2O2.

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KW - Electrochemistry

KW - Heme proteins

KW - N ligands

KW - O-O activation

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A functional model of cytochrome c oxidase: Thermodynamic implications

Abstract

Keywords

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