A 'click chemistry' approach to the efficient synthesis of modified nucleosides and oligonucleotides for PET imaging

Damien James, Jean Marc Escudier, Eric Amigues, Jürgen Schulz, Christiane Vitry, Thomas Bordenave, Magali Szlosek-Pinaud*, Eric Fouquet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Different thymidine derivatives bearing either an iodoaryl moiety at the 5′ position or a dialkylsilyl group at the 3′ position have been efficiently synthesized as precursors for carbon-11 or fluorine-18 labeling, respectively. Furthermore, iodoarylated thymidine derivatives have been incorporated into oligonucleotides giving an original way to label them with carbon-11.

Original languageEnglish
Pages (from-to)1230-1232
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number8
DOIs
Publication statusPublished - 24 Feb 2010
Externally publishedYes

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