@article{58212261f8a84bf5bcf65802898dcf69,
title = "Β-1,2,3-triazolyl-nucleosides as nicotinamide riboside mimics",
abstract = "The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.",
keywords = "Inhibition, Nucleoside, Nucleotide, Sirtuin",
author = "Amigues, {E. J.} and E. Armstrong and M. Dvorakova and Migaud, {M. E.} and M. Huang",
note = "Funding Information: Received 3 February 2009; accepted 4 March 2009. M. E. Migaud and M. Huang share joint authorship this article. The authors thank Professor R. Marmorstein and Ms. B. Sanders (from the Wistar Institute, Philadelphia, USA) for carrying out the preliminary inhibition studies and extensive discussions, and the EPSRC/MRC GR0100461 and the EC-FP6-EST program, which financially supported this work. Address correspondence to M. E. Migaud and M. Huang, School of Chemistry and Chemical Engineering, David Keir Building, Queen{\textquoteright}s University Belfast, Stranmillis Road, Belfast, BT9 5AG, Northern Ireland. E-mail: m.migaud@qub.ac.uk and m.huang@qub.ac.uk",
year = "2009",
month = mar,
doi = "10.1080/15257770902865415",
language = "English",
volume = "28",
pages = "238--259",
journal = "Nucleosides, Nucleotides and Nucleic Acids",
issn = "1525-7770",
number = "3",
}