ZIKV viral proteins and their roles in virus-host interactions

Moujian Guo; Lixia Hui; Yiwen Nie; Boris Tefsen; Ying Wu

doi:10.1007/s11427-020-1818-4

ZIKV viral proteins and their roles in virus-host interactions

Moujian Guo
, Lixia Hui
, Yiwen Nie
, Boris Tefsen
, Ying Wu^*

^*Corresponding author for this work

Department of Biosciences and Bioinformatics

Wuhan University
Hubei Province Key Laboratory of Allergy and Immunology

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

The re-emergence of Zika virus (ZIKV) and its associated neonatal microcephaly and Guillain-Barré syndrome have led the World Health Organization to declare a global health emergency. Until today, many related studies have successively reported the role of various viral proteins of ZIKV in the process of ZIKV infection and pathogenicity. These studies have provided significant insights for the treatment and prevention of ZIKV infection. Here we review the current research advances in the functional characterization of the interactions between each ZIKV viral protein and its host factors.

Original language	English
Pages (from-to)	709-719
Number of pages	11
Journal	Science China Life Sciences
Volume	64
Issue number	5
DOIs	https://doi.org/10.1007/s11427-020-1818-4
Publication status	Published - May 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ZIKV
host-virus interactions
immune response
pathogenicity
viral protein

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10.1007/s11427-020-1818-4

Cite this

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title = "ZIKV viral proteins and their roles in virus-host interactions",

abstract = "The re-emergence of Zika virus (ZIKV) and its associated neonatal microcephaly and Guillain-Barr{\'e} syndrome have led the World Health Organization to declare a global health emergency. Until today, many related studies have successively reported the role of various viral proteins of ZIKV in the process of ZIKV infection and pathogenicity. These studies have provided significant insights for the treatment and prevention of ZIKV infection. Here we review the current research advances in the functional characterization of the interactions between each ZIKV viral protein and its host factors.",

keywords = "ZIKV, host-virus interactions, immune response, pathogenicity, viral protein",

author = "Moujian Guo and Lixia Hui and Yiwen Nie and Boris Tefsen and Ying Wu",

note = "Funding Information: We thank Xinjie Nie at Tianjin Academy of Fine Arts, School of Experimental Art, Tianjin, China for drawing Figure 1. Publisher Copyright: {\textcopyright} 2020, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.",

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doi = "10.1007/s11427-020-1818-4",

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T1 - ZIKV viral proteins and their roles in virus-host interactions

AU - Guo, Moujian

AU - Hui, Lixia

AU - Nie, Yiwen

AU - Tefsen, Boris

AU - Wu, Ying

N1 - Funding Information: We thank Xinjie Nie at Tianjin Academy of Fine Arts, School of Experimental Art, Tianjin, China for drawing Figure 1. Publisher Copyright: © 2020, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2021/5

Y1 - 2021/5

N2 - The re-emergence of Zika virus (ZIKV) and its associated neonatal microcephaly and Guillain-Barré syndrome have led the World Health Organization to declare a global health emergency. Until today, many related studies have successively reported the role of various viral proteins of ZIKV in the process of ZIKV infection and pathogenicity. These studies have provided significant insights for the treatment and prevention of ZIKV infection. Here we review the current research advances in the functional characterization of the interactions between each ZIKV viral protein and its host factors.

AB - The re-emergence of Zika virus (ZIKV) and its associated neonatal microcephaly and Guillain-Barré syndrome have led the World Health Organization to declare a global health emergency. Until today, many related studies have successively reported the role of various viral proteins of ZIKV in the process of ZIKV infection and pathogenicity. These studies have provided significant insights for the treatment and prevention of ZIKV infection. Here we review the current research advances in the functional characterization of the interactions between each ZIKV viral protein and its host factors.

KW - ZIKV

KW - host-virus interactions

KW - immune response

KW - pathogenicity

KW - viral protein

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U2 - 10.1007/s11427-020-1818-4

DO - 10.1007/s11427-020-1818-4

M3 - Review article

C2 - 33068285

AN - SCOPUS:85092714201

SN - 1674-7305

VL - 64

SP - 709

EP - 719

JO - Science China Life Sciences

JF - Science China Life Sciences

IS - 5

ER -

ZIKV viral proteins and their roles in virus-host interactions

Abstract

UN SDGs

Keywords

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