X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

Lun Ma; Xiaoju Zou; Brian Bui; Wei Chen; Kwang Hyun Song; Timothy Solberg

doi:10.1063/1.4890105

X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

Lun Ma
, Xiaoju Zou
, Brian Bui
, Wei Chen^*
, Kwang Hyun Song
, Timothy Solberg

^*Corresponding author for this work

University of Texas at Arlington
University of Texas Southwestern Medical Center

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

Abstract

Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.

Original language	English
Article number	013702
Journal	Applied Physics Letters
Volume	105
Issue number	1
DOIs	https://doi.org/10.1063/1.4890105
Publication status	Published - 7 Jul 2014
Externally published	Yes

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10.1063/1.4890105

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title = "X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation",

abstract = "Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.",

author = "Lun Ma and Xiaoju Zou and Brian Bui and Wei Chen and Song, \{Kwang Hyun\} and Timothy Solberg",

note = "Publisher Copyright: {\textcopyright} 2014 AIP Publishing LLC.",

year = "2014",

month = jul,

day = "7",

doi = "10.1063/1.4890105",

language = "English",

volume = "105",

journal = "Applied Physics Letters",

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T1 - X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

AU - Ma, Lun

AU - Zou, Xiaoju

AU - Bui, Brian

AU - Chen, Wei

AU - Song, Kwang Hyun

AU - Solberg, Timothy

PY - 2014/7/7

Y1 - 2014/7/7

N2 - Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.

AB - Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.

UR - https://www.scopus.com/pages/publications/84908546288

U2 - 10.1063/1.4890105

DO - 10.1063/1.4890105

M3 - Article

AN - SCOPUS:84908546288

SN - 0003-6951

VL - 105

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 1

M1 - 013702

ER -

X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

Abstract

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