Understanding the genetic architectonics of complex CNS traits: Lost by the association, but found in the interaction?

Adam Michael Stewart; Michael Nguyen; Cai Song; Allan V. Kalueff

doi:10.1177/0269881115593904

Understanding the genetic architectonics of complex CNS traits: Lost by the association, but found in the interaction?

Adam Michael Stewart
, Michael Nguyen
, Cai Song
, Allan V. Kalueff^*

^*Corresponding author for this work

ZENEREI Institute
University of Virginia
Guangdong Ocean University
Dalhousie University
St. Petersburg State University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Recent evidence supports the value of endophenotypes and genome-wide association studies in psychiatric genetics, and their importance for dissecting the neural pathways and molecular mechanisms of complex neuropsychiatric disorders. Continuing this important discussion, here we outline three new mechanisms by which novel classes of genes may facilitate CNS pathogenesis without directly worsening its individual 'established' endophenotypes. These putative genetic mechanisms can apply to other human disorders in general, and may also be used for designing novel effective CNS drug treatments.

Original language	English
Pages (from-to)	872-877
Number of pages	6
Journal	Journal of Psychopharmacology
Volume	29
Issue number	8
DOIs	https://doi.org/10.1177/0269881115593904
Publication status	Published - 23 Aug 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Brain disorder
Endophenotype
Neuropsychiatric domain
Pathogenetic interplay/overlap
Spectrum of brain disorders

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10.1177/0269881115593904

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title = "Understanding the genetic architectonics of complex CNS traits: Lost by the association, but found in the interaction?",

abstract = "Recent evidence supports the value of endophenotypes and genome-wide association studies in psychiatric genetics, and their importance for dissecting the neural pathways and molecular mechanisms of complex neuropsychiatric disorders. Continuing this important discussion, here we outline three new mechanisms by which novel classes of genes may facilitate CNS pathogenesis without directly worsening its individual 'established' endophenotypes. These putative genetic mechanisms can apply to other human disorders in general, and may also be used for designing novel effective CNS drug treatments.",

keywords = "Brain disorder, Endophenotype, Neuropsychiatric domain, Pathogenetic interplay/overlap, Spectrum of brain disorders",

author = "Stewart, \{Adam Michael\} and Michael Nguyen and Cai Song and Kalueff, \{Allan V.\}",

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year = "2015",

month = aug,

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doi = "10.1177/0269881115593904",

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T1 - Understanding the genetic architectonics of complex CNS traits

T2 - Lost by the association, but found in the interaction?

AU - Stewart, Adam Michael

AU - Nguyen, Michael

AU - Song, Cai

AU - Kalueff, Allan V.

N1 - Publisher Copyright: © British Association for Psychopharmacology.

PY - 2015/8/23

Y1 - 2015/8/23

N2 - Recent evidence supports the value of endophenotypes and genome-wide association studies in psychiatric genetics, and their importance for dissecting the neural pathways and molecular mechanisms of complex neuropsychiatric disorders. Continuing this important discussion, here we outline three new mechanisms by which novel classes of genes may facilitate CNS pathogenesis without directly worsening its individual 'established' endophenotypes. These putative genetic mechanisms can apply to other human disorders in general, and may also be used for designing novel effective CNS drug treatments.

AB - Recent evidence supports the value of endophenotypes and genome-wide association studies in psychiatric genetics, and their importance for dissecting the neural pathways and molecular mechanisms of complex neuropsychiatric disorders. Continuing this important discussion, here we outline three new mechanisms by which novel classes of genes may facilitate CNS pathogenesis without directly worsening its individual 'established' endophenotypes. These putative genetic mechanisms can apply to other human disorders in general, and may also be used for designing novel effective CNS drug treatments.

KW - Brain disorder

KW - Endophenotype

KW - Neuropsychiatric domain

KW - Pathogenetic interplay/overlap

KW - Spectrum of brain disorders

UR - https://www.scopus.com/pages/publications/84937893857

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EP - 877

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

IS - 8

ER -

Understanding the genetic architectonics of complex CNS traits: Lost by the association, but found in the interaction?

Abstract

UN SDGs

Keywords

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