Understanding MicroRNA regulation: A computational perspective

Dong Yue; Jia Meng; Mingzhu Lu; C. L.Philip Chen; Maozu Guo; Yufei Huang

doi:10.1109/MSP.2011.943013

Understanding MicroRNA regulation: A computational perspective

Dong Yue^*
, Jia Meng
, Mingzhu Lu
, C. L.Philip Chen
, Maozu Guo
, Yufei Huang

^*Corresponding author for this work

University of Texas at San Antonio
Harbin Institute of Technology
Society of Operations Research

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Our knowledge of gene regulators presents an intrinsically unbalanced picture inadequate to fully explain the great complexity of their cellular functions. It is now understood that gene regulation assumes multiple modes including transcriptional regulation by transcription factors (TFs) and the posttranscriptional regulation by microRNA (miRNA). MiRNA is a class of small noncoding RNAs of ,22 nucleotides. It is known to repress transcription and/or inhibit translation of a large number of genes by binding mainly to the 3r untranslated region (UTR) of target genes [1], [2]. Elucidating specific functions of miRNAs comprises one of the most active research areas.

Original language	English
Article number	6105465
Pages (from-to)	77-88
Number of pages	12
Journal	IEEE Signal Processing Magazine
Volume	29
Issue number	1
DOIs	https://doi.org/10.1109/MSP.2011.943013
Publication status	Published - Jan 2012
Externally published	Yes

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title = "Understanding MicroRNA regulation: A computational perspective",

abstract = "Our knowledge of gene regulators presents an intrinsically unbalanced picture inadequate to fully explain the great complexity of their cellular functions. It is now understood that gene regulation assumes multiple modes including transcriptional regulation by transcription factors (TFs) and the posttranscriptional regulation by microRNA (miRNA). MiRNA is a class of small noncoding RNAs of ,22 nucleotides. It is known to repress transcription and/or inhibit translation of a large number of genes by binding mainly to the 3r untranslated region (UTR) of target genes [1], [2]. Elucidating specific functions of miRNAs comprises one of the most active research areas.",

author = "Dong Yue and Jia Meng and Mingzhu Lu and Chen, \{C. L.Philip\} and Maozu Guo and Yufei Huang",

note = "Funding Information: Yufei Huang is supported by the National Science Foundation (CCF-0546345), National Institute of Health (R01 CA096512), and Qatar National Research Fund (09-874-3-235). Maozu Guo is supported by the Natural Science Foundation of China (60932008 and 61172098) and Fundamental Research Funds for the Central Universities (HIT.ICRST.2010 022).",

year = "2012",

month = jan,

doi = "10.1109/MSP.2011.943013",

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AU - Meng, Jia

AU - Lu, Mingzhu

AU - Chen, C. L.Philip

AU - Guo, Maozu

AU - Huang, Yufei

N1 - Funding Information: Yufei Huang is supported by the National Science Foundation (CCF-0546345), National Institute of Health (R01 CA096512), and Qatar National Research Fund (09-874-3-235). Maozu Guo is supported by the Natural Science Foundation of China (60932008 and 61172098) and Fundamental Research Funds for the Central Universities (HIT.ICRST.2010 022).

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N2 - Our knowledge of gene regulators presents an intrinsically unbalanced picture inadequate to fully explain the great complexity of their cellular functions. It is now understood that gene regulation assumes multiple modes including transcriptional regulation by transcription factors (TFs) and the posttranscriptional regulation by microRNA (miRNA). MiRNA is a class of small noncoding RNAs of ,22 nucleotides. It is known to repress transcription and/or inhibit translation of a large number of genes by binding mainly to the 3r untranslated region (UTR) of target genes [1], [2]. Elucidating specific functions of miRNAs comprises one of the most active research areas.

AB - Our knowledge of gene regulators presents an intrinsically unbalanced picture inadequate to fully explain the great complexity of their cellular functions. It is now understood that gene regulation assumes multiple modes including transcriptional regulation by transcription factors (TFs) and the posttranscriptional regulation by microRNA (miRNA). MiRNA is a class of small noncoding RNAs of ,22 nucleotides. It is known to repress transcription and/or inhibit translation of a large number of genes by binding mainly to the 3r untranslated region (UTR) of target genes [1], [2]. Elucidating specific functions of miRNAs comprises one of the most active research areas.

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DO - 10.1109/MSP.2011.943013

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ER -

Understanding MicroRNA regulation: A computational perspective

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