[Tris(pyrazolyl)methane]ruthenium complexes capable of inhibiting cancer cell growth

Jesse M. Walker; Alexis McEwan; Roxanne Pycko; Mary Lynn Tassotto; Christine Gottardo; John Th'ng; Ruiyao Wang; Gregory J. Spivak

doi:10.1002/ejic.200900766

[Tris(pyrazolyl)methane]ruthenium complexes capable of inhibiting cancer cell growth

Jesse M. Walker
, Alexis McEwan
, Roxanne Pycko
, Mary Lynn Tassotto
, Christine Gottardo
, John Th'ng
, Ruiyao Wang
, Gregory J. Spivak

Lakehead University
Regional Cancer Care
Northern Ontario School of Medicine
Queen's University Kingston

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The [tris(pyrazolyl)methane]ruthenium complexes [(K³-tpm) RuCl(solv)₂]PF₆ [tpm = tris(pyrazolyl)methane; solv = MeCN, dmso] and [(K³-tpm)RuCl(LL)]PF₆ [LL = K ²-dppe, K²-dppp, K²-dppb, (PMePh ₂)₂] have been prepared, characterized and screened in vitro for their antiproliferative properties against the MCF-7 (breast) and HeLa (cervical) cancer cell lines by using the MTT assay. Although the MeCN and dmso complexes showed no activity under the conditions used, the phosphane complexes exhibited remarkable cytotoxic behaviour.

Original language	English
Pages (from-to)	4629-4633
Number of pages	5
Journal	European Journal of Inorganic Chemistry
Issue number	31
DOIs	https://doi.org/10.1002/ejic.200900766
Publication status	Published - Nov 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer agents
Antiproliferative assays
Half-sandwich complexes
Ruthenium
Tris(pyrazolyl)methane

Access to Document

10.1002/ejic.200900766

Cite this

@article{b036f2bd2f60410db114bedb0124b560,

title = "[Tris(pyrazolyl)methane]ruthenium complexes capable of inhibiting cancer cell growth",

abstract = "The [tris(pyrazolyl)methane]ruthenium complexes [(K3-tpm) RuCl(solv)2]PF6 [tpm = tris(pyrazolyl)methane; solv = MeCN, dmso] and [(K3-tpm)RuCl(LL)]PF6 [LL = K 2-dppe, K2-dppp, K2-dppb, (PMePh 2)2] have been prepared, characterized and screened in vitro for their antiproliferative properties against the MCF-7 (breast) and HeLa (cervical) cancer cell lines by using the MTT assay. Although the MeCN and dmso complexes showed no activity under the conditions used, the phosphane complexes exhibited remarkable cytotoxic behaviour.",

keywords = "Anticancer agents, Antiproliferative assays, Half-sandwich complexes, Ruthenium, Tris(pyrazolyl)methane",

author = "Walker, \{Jesse M.\} and Alexis McEwan and Roxanne Pycko and Tassotto, \{Mary Lynn\} and Christine Gottardo and John Th'ng and Ruiyao Wang and Spivak, \{Gregory J.\}",

year = "2009",

month = nov,

doi = "10.1002/ejic.200900766",

language = "English",

pages = "4629--4633",

journal = "European Journal of Inorganic Chemistry",

issn = "1434-1948",

number = "31",

}

TY - JOUR

T1 - [Tris(pyrazolyl)methane]ruthenium complexes capable of inhibiting cancer cell growth

AU - Walker, Jesse M.

AU - McEwan, Alexis

AU - Pycko, Roxanne

AU - Tassotto, Mary Lynn

AU - Gottardo, Christine

AU - Th'ng, John

AU - Wang, Ruiyao

AU - Spivak, Gregory J.

PY - 2009/11

Y1 - 2009/11

N2 - The [tris(pyrazolyl)methane]ruthenium complexes [(K3-tpm) RuCl(solv)2]PF6 [tpm = tris(pyrazolyl)methane; solv = MeCN, dmso] and [(K3-tpm)RuCl(LL)]PF6 [LL = K 2-dppe, K2-dppp, K2-dppb, (PMePh 2)2] have been prepared, characterized and screened in vitro for their antiproliferative properties against the MCF-7 (breast) and HeLa (cervical) cancer cell lines by using the MTT assay. Although the MeCN and dmso complexes showed no activity under the conditions used, the phosphane complexes exhibited remarkable cytotoxic behaviour.

AB - The [tris(pyrazolyl)methane]ruthenium complexes [(K3-tpm) RuCl(solv)2]PF6 [tpm = tris(pyrazolyl)methane; solv = MeCN, dmso] and [(K3-tpm)RuCl(LL)]PF6 [LL = K 2-dppe, K2-dppp, K2-dppb, (PMePh 2)2] have been prepared, characterized and screened in vitro for their antiproliferative properties against the MCF-7 (breast) and HeLa (cervical) cancer cell lines by using the MTT assay. Although the MeCN and dmso complexes showed no activity under the conditions used, the phosphane complexes exhibited remarkable cytotoxic behaviour.

KW - Anticancer agents

KW - Antiproliferative assays

KW - Half-sandwich complexes

KW - Ruthenium

KW - Tris(pyrazolyl)methane

UR - https://www.scopus.com/pages/publications/72149129164

U2 - 10.1002/ejic.200900766

DO - 10.1002/ejic.200900766

M3 - Article

AN - SCOPUS:72149129164

SN - 1434-1948

SP - 4629

EP - 4633

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 31

ER -

[Tris(pyrazolyl)methane]ruthenium complexes capable of inhibiting cancer cell growth

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this