TY - JOUR
T1 - Towards zebrafish models of migraine
AU - Xiao, Yubo
AU - Li, Zichen
AU - Yao, Haojun
AU - Wang, Yimeng
AU - Bai, Ruyue
AU - Yu, Zhili
AU - Wang, Gaomuyi
AU - He, Zhixuan
AU - Yang, Jingbo
AU - Chu, Jiale
AU - Pang, Yixuan
AU - Li, Qiuyin
AU - Cui, Jiahao
AU - Yang, Longen
AU - Stewart, Adam Michael
AU - Perfilova, Valentina N.
AU - Napo, Clement
AU - de Abreu, Murilo S.
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© 2025 Elsevier Inc.
PY - 2026/4
Y1 - 2026/4
N2 - Second among global disability causes, migraine is a severely debilitating neurological disorder that affects over 1 billion people. Recognized clinically for millennia, migraine exhibits complex multifactorial pathogenesis, whose mechanisms, risk factors, and therapy remain poorly understood. This also necessitates robust animal models that recapitulate this disorder. Complementing rodent models, the zebrafish (Danio rerio) is a commonly used organism in neuroscience research. Can these fish be used to study pathophysiology of migraine? Here, we discuss the developing utility of these fish for modeling migraine-like conditions and the potential for high-throughput pharmacological testing of its therapies. Critically evaluating the existing challenges of modeling migraine in zebrafish, we also outline potential future lines of research in this field.
AB - Second among global disability causes, migraine is a severely debilitating neurological disorder that affects over 1 billion people. Recognized clinically for millennia, migraine exhibits complex multifactorial pathogenesis, whose mechanisms, risk factors, and therapy remain poorly understood. This also necessitates robust animal models that recapitulate this disorder. Complementing rodent models, the zebrafish (Danio rerio) is a commonly used organism in neuroscience research. Can these fish be used to study pathophysiology of migraine? Here, we discuss the developing utility of these fish for modeling migraine-like conditions and the potential for high-throughput pharmacological testing of its therapies. Critically evaluating the existing challenges of modeling migraine in zebrafish, we also outline potential future lines of research in this field.
KW - Experimental models
KW - Migraine
KW - Pathobiological mechanisms
KW - Translational neurology
KW - Zebrafish
UR - https://www.scopus.com/pages/publications/105027253091
U2 - 10.1016/j.expneurol.2025.115627
DO - 10.1016/j.expneurol.2025.115627
M3 - Review article
C2 - 41482109
AN - SCOPUS:105027253091
SN - 0014-4886
VL - 398
JO - Experimental Neurology
JF - Experimental Neurology
M1 - 115627
ER -