Total synthesis of the highly N-methylated peptides carmabin a and dragomabin

Baijun Ye; Peng Jiang; Tingrong Zhang; Yuanjun Sun; Xin Hao; Yingjun Cui; Liang Wang; Yue Chen

doi:10.3390/md16090338

Total synthesis of the highly N-methylated peptides carmabin a and dragomabin

Baijun Ye
, Peng Jiang
, Tingrong Zhang
, Yuanjun Sun
, Xin Hao
, Yingjun Cui
, Liang Wang^*
, Yue Chen

^*Corresponding author for this work

Nankai University
Collaborative Innovation Center of Chemical Science and Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

Original language	English
Article number	338
Journal	Marine Drugs
Volume	16
Issue number	9
DOIs	https://doi.org/10.3390/md16090338
Publication status	Published - 17 Sept 2018
Externally published	Yes

Keywords

Carmabin A
Dragomabin
Stereochemical determination/revision
Total synthesis

Access to Document

10.3390/md16090338

Cite this

@article{dadd3f986a0941338a78b258acbe246d,

title = "Total synthesis of the highly N-methylated peptides carmabin a and dragomabin",

abstract = "The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.",

keywords = "Carmabin A, Dragomabin, Stereochemical determination/revision, Total synthesis",

author = "Baijun Ye and Peng Jiang and Tingrong Zhang and Yuanjun Sun and Xin Hao and Yingjun Cui and Liang Wang and Yue Chen",

note = "Publisher Copyright: {\textcopyright} 2018 by the Authors.",

year = "2018",

month = sep,

day = "17",

doi = "10.3390/md16090338",

language = "English",

volume = "16",

journal = "Marine Drugs",

issn = "1660-3397",

number = "9",

}

TY - JOUR

T1 - Total synthesis of the highly N-methylated peptides carmabin a and dragomabin

AU - Ye, Baijun

AU - Jiang, Peng

AU - Zhang, Tingrong

AU - Sun, Yuanjun

AU - Hao, Xin

AU - Cui, Yingjun

AU - Wang, Liang

AU - Chen, Yue

PY - 2018/9/17

Y1 - 2018/9/17

N2 - The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

AB - The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

KW - Carmabin A

KW - Dragomabin

KW - Stereochemical determination/revision

KW - Total synthesis

UR - https://www.scopus.com/pages/publications/85053843984

U2 - 10.3390/md16090338

DO - 10.3390/md16090338

M3 - Article

C2 - 30227592

AN - SCOPUS:85053843984

SN - 1660-3397

VL - 16

JO - Marine Drugs

JF - Marine Drugs

IS - 9

M1 - 338

ER -

Total synthesis of the highly N-methylated peptides carmabin a and dragomabin

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this