Total Synthesis of the Highly N-Methylated Peptide Jahanyne

Baijun Ye; Peng Jiang; Tingrong Zhang; Yahui Ding; Yuanjun Sun; Xin Hao; Lanshu Li; Liang Wang; Yue Chen

doi:10.1021/acs.joc.8b00503

Total Synthesis of the Highly N-Methylated Peptide Jahanyne

Baijun Ye, Peng Jiang, Tingrong Zhang, Yahui Ding, Yuanjun Sun, Xin Hao, Lanshu Li, Liang Wang^*, Yue Chen

^*Corresponding author for this work

Nankai University

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Total synthesis of jahanyne (1) was achieved from commercially available materials on a 38 mg scale. The Boc-N-Me-L-Val-OH fragment along with the HATU/DIPEA coupling condition was applied to avoid the diketopiperazine side reaction in solution phase synthesis.

Original language	English
Pages (from-to)	6741-6747
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	83
Issue number	12
DOIs	https://doi.org/10.1021/acs.joc.8b00503
Publication status	Published - 15 Jun 2018
Externally published	Yes

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10.1021/acs.joc.8b00503

Cite this

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title = "Total Synthesis of the Highly N-Methylated Peptide Jahanyne",

abstract = "Total synthesis of jahanyne (1) was achieved from commercially available materials on a 38 mg scale. The Boc-N-Me-L-Val-OH fragment along with the HATU/DIPEA coupling condition was applied to avoid the diketopiperazine side reaction in solution phase synthesis.",

author = "Baijun Ye and Peng Jiang and Tingrong Zhang and Yahui Ding and Yuanjun Sun and Xin Hao and Lanshu Li and Liang Wang and Yue Chen",

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doi = "10.1021/acs.joc.8b00503",

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T1 - Total Synthesis of the Highly N-Methylated Peptide Jahanyne

AU - Ye, Baijun

AU - Jiang, Peng

AU - Zhang, Tingrong

AU - Ding, Yahui

AU - Sun, Yuanjun

AU - Hao, Xin

AU - Li, Lanshu

AU - Wang, Liang

AU - Chen, Yue

PY - 2018/6/15

Y1 - 2018/6/15

N2 - Total synthesis of jahanyne (1) was achieved from commercially available materials on a 38 mg scale. The Boc-N-Me-L-Val-OH fragment along with the HATU/DIPEA coupling condition was applied to avoid the diketopiperazine side reaction in solution phase synthesis.

AB - Total synthesis of jahanyne (1) was achieved from commercially available materials on a 38 mg scale. The Boc-N-Me-L-Val-OH fragment along with the HATU/DIPEA coupling condition was applied to avoid the diketopiperazine side reaction in solution phase synthesis.

UR - https://www.scopus.com/pages/publications/85047639873

U2 - 10.1021/acs.joc.8b00503

DO - 10.1021/acs.joc.8b00503

M3 - Article

C2 - 29798667

AN - SCOPUS:85047639873

SN - 0022-3263

VL - 83

SP - 6741

EP - 6747

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 12

ER -

Total Synthesis of the Highly N-Methylated Peptide Jahanyne

Abstract

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