Total synthesis of BE-43547A2

Yuanjun Sun; Xiuwen Su; Ruifei Zhou; Dehong Wang; Yuan Zhao; Yuhang Jiang; Liang Wang; Yue Chen

doi:10.1016/j.tet.2018.08.030

Total synthesis of BE-43547A₂

Yuanjun Sun, Xiuwen Su, Ruifei Zhou, Dehong Wang, Yuan Zhao, Yuhang Jiang, Liang Wang, Yue Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

An asymmetric total synthesis of BE-43547A₂ has been achieved in 16 steps (longest linear) on a 3.2 gram scale. The details of our efforts that led to the total synthesis of BE-43547A₂ were reported, the final 6 steps were optimized, and the overall yield was improved from 4.5% to 9.7%. The procedure utilized in the final 2 steps may serve as a better method for separating unstable APD compounds.

Original language	English
Pages (from-to)	5955-5964
Number of pages	10
Journal	Tetrahedron
Volume	74
Issue number	40
DOIs	https://doi.org/10.1016/j.tet.2018.08.030
Publication status	Published - 4 Oct 2018
Externally published	Yes

Keywords

BE-43547
Hypoxia-selective
Pancreatic cancer
Total synthesis
α-Hydroxylation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tet.2018.08.030

Cite this

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title = "Total synthesis of BE-43547A2 ",

abstract = "An asymmetric total synthesis of BE-43547A2 has been achieved in 16 steps (longest linear) on a 3.2 gram scale. The details of our efforts that led to the total synthesis of BE-43547A2 were reported, the final 6 steps were optimized, and the overall yield was improved from 4.5\% to 9.7\%. The procedure utilized in the final 2 steps may serve as a better method for separating unstable APD compounds.",

keywords = "BE-43547, Hypoxia-selective, Pancreatic cancer, Total synthesis, α-Hydroxylation",

author = "Yuanjun Sun and Xiuwen Su and Ruifei Zhou and Dehong Wang and Yuan Zhao and Yuhang Jiang and Liang Wang and Yue Chen",

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T1 - Total synthesis of BE-43547A2

AU - Sun, Yuanjun

AU - Su, Xiuwen

AU - Zhou, Ruifei

AU - Wang, Dehong

AU - Zhao, Yuan

AU - Jiang, Yuhang

AU - Wang, Liang

AU - Chen, Yue

PY - 2018/10/4

Y1 - 2018/10/4

N2 - An asymmetric total synthesis of BE-43547A2 has been achieved in 16 steps (longest linear) on a 3.2 gram scale. The details of our efforts that led to the total synthesis of BE-43547A2 were reported, the final 6 steps were optimized, and the overall yield was improved from 4.5% to 9.7%. The procedure utilized in the final 2 steps may serve as a better method for separating unstable APD compounds.

AB - An asymmetric total synthesis of BE-43547A2 has been achieved in 16 steps (longest linear) on a 3.2 gram scale. The details of our efforts that led to the total synthesis of BE-43547A2 were reported, the final 6 steps were optimized, and the overall yield was improved from 4.5% to 9.7%. The procedure utilized in the final 2 steps may serve as a better method for separating unstable APD compounds.

KW - BE-43547

KW - Hypoxia-selective

KW - Pancreatic cancer

KW - Total synthesis

KW - α-Hydroxylation

UR - https://www.scopus.com/pages/publications/85052287115

U2 - 10.1016/j.tet.2018.08.030

DO - 10.1016/j.tet.2018.08.030

M3 - Article

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VL - 74

SP - 5955

EP - 5964

JO - Tetrahedron

JF - Tetrahedron

IS - 40

ER -