Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

Md Tanvir Kabir; Md Habibur Rahman; Muddaser Shah; Mohd Raeed Jamiruddin; Debasish Basak; Ahmed Al-Harrasi; Saurabh Bhatia; Ghulam Md Ashraf; Agnieszka Najda; Attalla F. El-kott; Hanan R.H. Mohamed; Hamdan S. Al-malky; Mousa O. Germoush; Ahmed E. Altyar; Esraa B. Alwafai; Nehmat Ghaboura; Mohamed M. Abdel-Daim

doi:10.1016/j.biopha.2021.112610

Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

Md Tanvir Kabir
, Md Habibur Rahman^*
, Muddaser Shah
, Mohd Raeed Jamiruddin
, Debasish Basak
, Ahmed Al-Harrasi
, Saurabh Bhatia
, Ghulam Md Ashraf
, Agnieszka Najda^*
, Attalla F. El-kott
, Hanan R.H. Mohamed
, Hamdan S. Al-malky
, Mousa O. Germoush
, Ahmed E. Altyar
, Esraa B. Alwafai
, Nehmat Ghaboura
, Mohamed M. Abdel-Daim^*

^*Corresponding author for this work

BRAC University
Southeast University, Dhaka
Yonsei University Mirae Campus
Abdul Wali Khan University Mardan
Florida International University
University of Nizwa
University of Petroleum and Energy Studies
Pre-Clinical Research Unit
King Abdulaziz University
Department of Medical Laboratory Technology
University of Life Sciences in Lublin
King Khalid University
Damanhour University
Cairo University
Ministry of Health, Saudi Arabia
Al Jouf University
Batterjee Medical College
Suez Canal University

Research output: Contribution to journal › Review article › peer-review

162 Citations (Scopus)

Abstract

Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have various disease-specific causal factors and pathological features. A very common characteristic of NDs is oxidative stress (OS), which takes place due to the elevated generation of reactive oxygen species during the progression of NDs. Furthermore, the pathological condition of NDs including an increased level of protein aggregates can further lead to chronic inflammation because of the microglial activation. Carotenoids (CTs) are naturally occurring pigments that play a significant role in averting brain disorders. More than 750 CTs are present in nature, and they are widely available in plants, microorganisms, and animals. CTs are accountable for the red, yellow, and orange pigments in several animals and plants, and these colors usually indicate various types of CTs. CTs exert various bioactive properties because of its characteristic structure, including anti-inflammatory and antioxidant properties. Due to the protective properties of CTs, levels of CTs in the human body have been markedly linked with the prevention and treatment of multiple diseases including NDs. In this review, we have summarized the relationship between OS, neuroinflammation, and NDs. In addition, we have also particularly focused on the antioxidants and anti-inflammatory properties of CTs in the management of NDs.

Original language	English
Article number	112610
Journal	Biomedicine and Pharmacotherapy
Volume	146
DOIs	https://doi.org/10.1016/j.biopha.2021.112610
Publication status	Published - Feb 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-inflammatory
Antioxidant
Inflammation
Microglia
Neurodegenerative disorders
Oxidative stress

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10.1016/j.biopha.2021.112610

Cite this

Kabir, M. T., Rahman, M. H., Shah, M., Jamiruddin, M. R., Basak, D., Al-Harrasi, A., Bhatia, S., Ashraf, G. M., Najda, A., El-kott, A. F., Mohamed, H. R. H., Al-malky, H. S., Germoush, M. O., Altyar, A. E., Alwafai, E. B., Ghaboura, N., & Abdel-Daim, M. M. (2022). Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders. Biomedicine and Pharmacotherapy, 146, Article 112610. https://doi.org/10.1016/j.biopha.2021.112610

@article{4540a73e096a42a8a86f64f9319f36de,

title = "Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders",

abstract = "Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have various disease-specific causal factors and pathological features. A very common characteristic of NDs is oxidative stress (OS), which takes place due to the elevated generation of reactive oxygen species during the progression of NDs. Furthermore, the pathological condition of NDs including an increased level of protein aggregates can further lead to chronic inflammation because of the microglial activation. Carotenoids (CTs) are naturally occurring pigments that play a significant role in averting brain disorders. More than 750 CTs are present in nature, and they are widely available in plants, microorganisms, and animals. CTs are accountable for the red, yellow, and orange pigments in several animals and plants, and these colors usually indicate various types of CTs. CTs exert various bioactive properties because of its characteristic structure, including anti-inflammatory and antioxidant properties. Due to the protective properties of CTs, levels of CTs in the human body have been markedly linked with the prevention and treatment of multiple diseases including NDs. In this review, we have summarized the relationship between OS, neuroinflammation, and NDs. In addition, we have also particularly focused on the antioxidants and anti-inflammatory properties of CTs in the management of NDs.",

keywords = "Anti-inflammatory, Antioxidant, Inflammation, Microglia, Neurodegenerative disorders, Oxidative stress",

author = "Kabir, \{Md Tanvir\} and Rahman, \{Md Habibur\} and Muddaser Shah and Jamiruddin, \{Mohd Raeed\} and Debasish Basak and Ahmed Al-Harrasi and Saurabh Bhatia and Ashraf, \{Ghulam Md\} and Agnieszka Najda and El-kott, \{Attalla F.\} and Mohamed, \{Hanan R.H.\} and Al-malky, \{Hamdan S.\} and Germoush, \{Mousa O.\} and Altyar, \{Ahmed E.\} and Alwafai, \{Esraa B.\} and Nehmat Ghaboura and Abdel-Daim, \{Mohamed M.\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = feb,

doi = "10.1016/j.biopha.2021.112610",

language = "English",

volume = "146",

journal = "Biomedicine and Pharmacotherapy",

issn = "0753-3322",

}

Kabir, MT, Rahman, MH, Shah, M, Jamiruddin, MR, Basak, D, Al-Harrasi, A, Bhatia, S, Ashraf, GM, Najda, A, El-kott, AF, Mohamed, HRH, Al-malky, HS, Germoush, MO, Altyar, AE, Alwafai, EB, Ghaboura, N & Abdel-Daim, MM 2022, 'Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders', Biomedicine and Pharmacotherapy, vol. 146, 112610. https://doi.org/10.1016/j.biopha.2021.112610

TY - JOUR

T1 - Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

AU - Kabir, Md Tanvir

AU - Rahman, Md Habibur

AU - Shah, Muddaser

AU - Jamiruddin, Mohd Raeed

AU - Basak, Debasish

AU - Al-Harrasi, Ahmed

AU - Bhatia, Saurabh

AU - Ashraf, Ghulam Md

AU - Najda, Agnieszka

AU - El-kott, Attalla F.

AU - Mohamed, Hanan R.H.

AU - Al-malky, Hamdan S.

AU - Germoush, Mousa O.

AU - Altyar, Ahmed E.

AU - Alwafai, Esraa B.

AU - Ghaboura, Nehmat

AU - Abdel-Daim, Mohamed M.

PY - 2022/2

Y1 - 2022/2

N2 - Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have various disease-specific causal factors and pathological features. A very common characteristic of NDs is oxidative stress (OS), which takes place due to the elevated generation of reactive oxygen species during the progression of NDs. Furthermore, the pathological condition of NDs including an increased level of protein aggregates can further lead to chronic inflammation because of the microglial activation. Carotenoids (CTs) are naturally occurring pigments that play a significant role in averting brain disorders. More than 750 CTs are present in nature, and they are widely available in plants, microorganisms, and animals. CTs are accountable for the red, yellow, and orange pigments in several animals and plants, and these colors usually indicate various types of CTs. CTs exert various bioactive properties because of its characteristic structure, including anti-inflammatory and antioxidant properties. Due to the protective properties of CTs, levels of CTs in the human body have been markedly linked with the prevention and treatment of multiple diseases including NDs. In this review, we have summarized the relationship between OS, neuroinflammation, and NDs. In addition, we have also particularly focused on the antioxidants and anti-inflammatory properties of CTs in the management of NDs.

AB - Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have various disease-specific causal factors and pathological features. A very common characteristic of NDs is oxidative stress (OS), which takes place due to the elevated generation of reactive oxygen species during the progression of NDs. Furthermore, the pathological condition of NDs including an increased level of protein aggregates can further lead to chronic inflammation because of the microglial activation. Carotenoids (CTs) are naturally occurring pigments that play a significant role in averting brain disorders. More than 750 CTs are present in nature, and they are widely available in plants, microorganisms, and animals. CTs are accountable for the red, yellow, and orange pigments in several animals and plants, and these colors usually indicate various types of CTs. CTs exert various bioactive properties because of its characteristic structure, including anti-inflammatory and antioxidant properties. Due to the protective properties of CTs, levels of CTs in the human body have been markedly linked with the prevention and treatment of multiple diseases including NDs. In this review, we have summarized the relationship between OS, neuroinflammation, and NDs. In addition, we have also particularly focused on the antioxidants and anti-inflammatory properties of CTs in the management of NDs.

KW - Anti-inflammatory

KW - Antioxidant

KW - Inflammation

KW - Microglia

KW - Neurodegenerative disorders

KW - Oxidative stress

UR - https://www.scopus.com/pages/publications/85122153584

U2 - 10.1016/j.biopha.2021.112610

DO - 10.1016/j.biopha.2021.112610

M3 - Review article

C2 - 35062074

AN - SCOPUS:85122153584

SN - 0753-3322

VL - 146

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

M1 - 112610

ER -

Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

Abstract

UN SDGs

Keywords

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