The vitamin D neuroendocrine system as a target for novel neurotropic drugs

A. V. Kalueff; A. Minasyan; T. Keisala; M. Kuuslahti; S. Miettinen; P. Tuohimaa

doi:10.2174/187152706784111506

The vitamin D neuroendocrine system as a target for novel neurotropic drugs

A. V. Kalueff^*
, A. Minasyan
, T. Keisala
, M. Kuuslahti
, S. Miettinen
, P. Tuohimaa

^*Corresponding author for this work

Department of Anatomy
Tampere University
Department of Clinical Chemistry

Research output: Contribution to journal › Review article › peer-review

59 Citations (Scopus)

Abstract

Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions.

Original language	English
Pages (from-to)	363-371
Number of pages	9
Journal	CNS and Neurological Disorders - Drug Targets
Volume	5
Issue number	3
DOIs	https://doi.org/10.2174/187152706784111506
Publication status	Published - Jun 2006
Externally published	Yes

Keywords

Brain disorders
Neurosteroid hormone
New drugs
Vitamin D

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10.2174/187152706784111506

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title = "The vitamin D neuroendocrine system as a target for novel neurotropic drugs",

abstract = "Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions.",

keywords = "Brain disorders, Neurosteroid hormone, New drugs, Vitamin D",

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language = "English",

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T1 - The vitamin D neuroendocrine system as a target for novel neurotropic drugs

AU - Kalueff, A. V.

AU - Minasyan, A.

AU - Keisala, T.

AU - Kuuslahti, M.

AU - Miettinen, S.

AU - Tuohimaa, P.

PY - 2006/6

Y1 - 2006/6

N2 - Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions.

AB - Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions.

KW - Brain disorders

KW - Neurosteroid hormone

KW - New drugs

KW - Vitamin D

UR - https://www.scopus.com/pages/publications/33745115907

U2 - 10.2174/187152706784111506

DO - 10.2174/187152706784111506

M3 - Review article

C2 - 16787236

AN - SCOPUS:33745115907

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VL - 5

SP - 363

EP - 371

JO - CNS and Neurological Disorders - Drug Targets

JF - CNS and Neurological Disorders - Drug Targets

IS - 3

ER -

The vitamin D neuroendocrine system as a target for novel neurotropic drugs

Abstract

Keywords

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