The smell of "anxiety": Behavioral modulation by experimental anosmia in zebrafish

Murilo S. Abreu; Ana C.V.V. Giacomini; Allan V. Kalueff; Leonardo J.G. Barcellos

doi:10.1016/j.physbeh.2016.01.030

The smell of "anxiety": Behavioral modulation by experimental anosmia in zebrafish

Murilo S. Abreu
, Ana C.V.V. Giacomini
, Allan V. Kalueff
, Leonardo J.G. Barcellos^*

^*Corresponding author for this work

Universidade Federal de Santa Maria
Universidade de Passo Fundo
Guangdong Ocean University
St. Petersburg State University
Ural Federal University
ZENEREI Institute
International Zebrafish Neuroscience Research Consortium (ZNRC)

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Olfaction is strongly involved in the regulation of fish behavior, including reproductive, defensive, social and migration behaviors. In fish, anosmia (the lack of olfaction) can be induced experimentally, impairing their ability to respond to various olfactory stimuli. Here, we examine the effects of experimental lidocaine-induced anosmia on anxiety-like behavior and whole-body cortisol levels in adult zebrafish (Danio rerio). We show that experimentally-induced anosmia reduces anxiolytic-like behavioral effects of fluoxetine and seems to interact with anxiogenic effect of stress also paralleling cortisol responses in zebrafish. These findings provide first experimental evidence that temporary anosmia modulates anxiety-like behaviors and physiology in adult zebrafish.

Original language	English
Pages (from-to)	67-71
Number of pages	5
Journal	Physiology and Behavior
Volume	157
DOIs	https://doi.org/10.1016/j.physbeh.2016.01.030
Publication status	Published - 1 Apr 2016
Externally published	Yes

Keywords

Fluoxetine
Food odor
Novel tank
Olfactory sense
Stress

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10.1016/j.physbeh.2016.01.030

Cite this

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title = "The smell of {"}anxiety{"}: Behavioral modulation by experimental anosmia in zebrafish",

abstract = "Olfaction is strongly involved in the regulation of fish behavior, including reproductive, defensive, social and migration behaviors. In fish, anosmia (the lack of olfaction) can be induced experimentally, impairing their ability to respond to various olfactory stimuli. Here, we examine the effects of experimental lidocaine-induced anosmia on anxiety-like behavior and whole-body cortisol levels in adult zebrafish (Danio rerio). We show that experimentally-induced anosmia reduces anxiolytic-like behavioral effects of fluoxetine and seems to interact with anxiogenic effect of stress also paralleling cortisol responses in zebrafish. These findings provide first experimental evidence that temporary anosmia modulates anxiety-like behaviors and physiology in adult zebrafish.",

keywords = "Fluoxetine, Food odor, Novel tank, Olfactory sense, Stress",

author = "Abreu, \{Murilo S.\} and Giacomini, \{Ana C.V.V.\} and Kalueff, \{Allan V.\} and Barcellos, \{Leonardo J.G.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2016",

month = apr,

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doi = "10.1016/j.physbeh.2016.01.030",

language = "English",

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journal = "Physiology and Behavior",

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TY - JOUR

T1 - The smell of "anxiety"

T2 - Behavioral modulation by experimental anosmia in zebrafish

AU - Abreu, Murilo S.

AU - Giacomini, Ana C.V.V.

AU - Kalueff, Allan V.

AU - Barcellos, Leonardo J.G.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Olfaction is strongly involved in the regulation of fish behavior, including reproductive, defensive, social and migration behaviors. In fish, anosmia (the lack of olfaction) can be induced experimentally, impairing their ability to respond to various olfactory stimuli. Here, we examine the effects of experimental lidocaine-induced anosmia on anxiety-like behavior and whole-body cortisol levels in adult zebrafish (Danio rerio). We show that experimentally-induced anosmia reduces anxiolytic-like behavioral effects of fluoxetine and seems to interact with anxiogenic effect of stress also paralleling cortisol responses in zebrafish. These findings provide first experimental evidence that temporary anosmia modulates anxiety-like behaviors and physiology in adult zebrafish.

AB - Olfaction is strongly involved in the regulation of fish behavior, including reproductive, defensive, social and migration behaviors. In fish, anosmia (the lack of olfaction) can be induced experimentally, impairing their ability to respond to various olfactory stimuli. Here, we examine the effects of experimental lidocaine-induced anosmia on anxiety-like behavior and whole-body cortisol levels in adult zebrafish (Danio rerio). We show that experimentally-induced anosmia reduces anxiolytic-like behavioral effects of fluoxetine and seems to interact with anxiogenic effect of stress also paralleling cortisol responses in zebrafish. These findings provide first experimental evidence that temporary anosmia modulates anxiety-like behaviors and physiology in adult zebrafish.

KW - Fluoxetine

KW - Food odor

KW - Novel tank

KW - Olfactory sense

KW - Stress

UR - https://www.scopus.com/pages/publications/84956598492

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DO - 10.1016/j.physbeh.2016.01.030

M3 - Article

C2 - 26821184

AN - SCOPUS:84956598492

SN - 0031-9384

VL - 157

SP - 67

EP - 71

JO - Physiology and Behavior

JF - Physiology and Behavior

ER -

The smell of "anxiety": Behavioral modulation by experimental anosmia in zebrafish

Abstract

Keywords

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