The origins of SARS-CoV-2: A critical review

Edward C. Holmes; Stephen A. Goldstein; Angela L. Rasmussen; David L. Robertson; Alexander Crits-Christoph; Joel O. Wertheim; Simon J. Anthony; Wendy S. Barclay; Maciej F. Boni; Peter C. Doherty; Jeremy Farrar; Jemma L. Geoghegan; Xiaowei Jiang; Julian L. Leibowitz; Stuart J.D. Neil; Tim Skern; Susan R. Weiss; Michael Worobey; Kristian G. Andersen; Robert F. Garry; Andrew Rambaut

doi:10.1016/j.cell.2021.08.017

The origins of SARS-CoV-2: A critical review

Edward C. Holmes^*
, Stephen A. Goldstein
, Angela L. Rasmussen
, David L. Robertson
, Alexander Crits-Christoph
, Joel O. Wertheim
, Simon J. Anthony
, Wendy S. Barclay
, Maciej F. Boni
, Peter C. Doherty
, Jeremy Farrar
, Jemma L. Geoghegan
, Xiaowei Jiang
, Julian L. Leibowitz
, Stuart J.D. Neil
, Tim Skern
, Susan R. Weiss
, Michael Worobey
, Kristian G. Andersen
, Robert F. Garry

Andrew Rambaut^*

^*Corresponding author for this work

Department of Biosciences and Bioinformatics

University of Sydney
University of Utah
University of Saskatchewan
MRC-University of Glasgow Centre for Virus Research
University of California at Berkeley
University of California at San Diego
University of California at Davis
Imperial College London
Pennsylvania State University
University of Melbourne
Wellcome Trust
University of Otago
ESR
Texas A&M University
Guy's and St Thomas' NHS Foundation Trust
Medical University of Vienna
University of Pennsylvania
University of Arizona
Scripps Research Institute
Tulane University
Zalgen Labs
University of Edinburgh

Research output: Contribution to journal › Review article › peer-review

397 Citations (Scopus)

Abstract

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

Original language	English
Pages (from-to)	4848-4856
Number of pages	9
Journal	Cell
Volume	184
Issue number	19
DOIs	https://doi.org/10.1016/j.cell.2021.08.017
Publication status	Published - 16 Sept 2021

Keywords

COVID-19
SARS-CoV-2
evolution
origins
zoonosis

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Holmes, E. C., Goldstein, S. A., Rasmussen, A. L., Robertson, D. L., Crits-Christoph, A., Wertheim, J. O., Anthony, S. J., Barclay, W. S., Boni, M. F., Doherty, P. C., Farrar, J., Geoghegan, J. L., Jiang, X., Leibowitz, J. L., Neil, S. J. D., Skern, T., Weiss, S. R., Worobey, M., Andersen, K. G., ... Rambaut, A. (2021). The origins of SARS-CoV-2: A critical review. Cell, 184(19), 4848-4856. https://doi.org/10.1016/j.cell.2021.08.017

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title = "The origins of SARS-CoV-2: A critical review",

abstract = "Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.",

keywords = "COVID-19, SARS-CoV-2, evolution, origins, zoonosis",

author = "Holmes, \{Edward C.\} and Goldstein, \{Stephen A.\} and Rasmussen, \{Angela L.\} and Robertson, \{David L.\} and Alexander Crits-Christoph and Wertheim, \{Joel O.\} and Anthony, \{Simon J.\} and Barclay, \{Wendy S.\} and Boni, \{Maciej F.\} and Doherty, \{Peter C.\} and Jeremy Farrar and Geoghegan, \{Jemma L.\} and Xiaowei Jiang and Leibowitz, \{Julian L.\} and Neil, \{Stuart J.D.\} and Tim Skern and Weiss, \{Susan R.\} and Michael Worobey and Andersen, \{Kristian G.\} and Garry, \{Robert F.\} and Andrew Rambaut",

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year = "2021",

month = sep,

day = "16",

doi = "10.1016/j.cell.2021.08.017",

language = "English",

volume = "184",

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Holmes, EC, Goldstein, SA, Rasmussen, AL, Robertson, DL, Crits-Christoph, A, Wertheim, JO, Anthony, SJ, Barclay, WS, Boni, MF, Doherty, PC, Farrar, J, Geoghegan, JL, Jiang, X, Leibowitz, JL, Neil, SJD, Skern, T, Weiss, SR, Worobey, M, Andersen, KG, Garry, RF & Rambaut, A 2021, 'The origins of SARS-CoV-2: A critical review', Cell, vol. 184, no. 19, pp. 4848-4856. https://doi.org/10.1016/j.cell.2021.08.017

TY - JOUR

T1 - The origins of SARS-CoV-2

T2 - A critical review

AU - Holmes, Edward C.

AU - Goldstein, Stephen A.

AU - Rasmussen, Angela L.

AU - Robertson, David L.

AU - Crits-Christoph, Alexander

AU - Wertheim, Joel O.

AU - Anthony, Simon J.

AU - Barclay, Wendy S.

AU - Boni, Maciej F.

AU - Doherty, Peter C.

AU - Farrar, Jeremy

AU - Geoghegan, Jemma L.

AU - Jiang, Xiaowei

AU - Leibowitz, Julian L.

AU - Neil, Stuart J.D.

AU - Skern, Tim

AU - Weiss, Susan R.

AU - Worobey, Michael

AU - Andersen, Kristian G.

AU - Garry, Robert F.

AU - Rambaut, Andrew

PY - 2021/9/16

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N2 - Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

AB - Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

KW - COVID-19

KW - SARS-CoV-2

KW - evolution

KW - origins

KW - zoonosis

UR - https://www.scopus.com/pages/publications/85113721848

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DO - 10.1016/j.cell.2021.08.017

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C2 - 34480864

AN - SCOPUS:85113721848

SN - 0092-8674

VL - 184

SP - 4848

EP - 4856

JO - Cell

JF - Cell

IS - 19

ER -

The origins of SARS-CoV-2: A critical review

Abstract

Keywords

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