The Fractal Viewpoint of Tumors and Nanoparticles

Athanasios Alexiou; Christos Tsagkaris; Stylianos Chatzichronis; Andreas Koulouris; Ioannis Haranas; Ioannis Gkigkitzis; Georgios Zouganelis; Nobendu Mukerjee; Swastika Maitra; Niraj Kumar Jha; Gaber El Saber Batiha; Mohammad Amjad Kamal; Michail Nikolaou; Ghulam Md Ashraf

doi:10.2174/0929867329666220801152347

The Fractal Viewpoint of Tumors and Nanoparticles

Athanasios Alexiou^*
, Christos Tsagkaris
, Stylianos Chatzichronis
, Andreas Koulouris
, Ioannis Haranas
, Ioannis Gkigkitzis
, Georgios Zouganelis
, Nobendu Mukerjee
, Swastika Maitra
, Niraj Kumar Jha
, Gaber El Saber Batiha
, Mohammad Amjad Kamal
, Michail Nikolaou
, Ghulam Md Ashraf

^*Corresponding author for this work

Novel Global Community Educational Foundation
AFNP Med
Public Health and Policy Working Group
Karolinska Institutet
University of Crete
Wilfrid Laurier University
NOVA
University of Derby
West Bengal State University
Adamas University
Sharda University
Uttaranchal University
Chandigarh University
Damanhour University
Sichuan University
King Abdulaziz University
Daffodil International University
Oncology Hospital
Pre-Clinical Research Unit
Department of Medical Laboratory Technology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Even though the promising therapies against cancer are rapidly improved, the oncology patients population has seen exponential growth, placing cancer in 5^th place among the ten deadliest diseases. Efficient drug delivery systems must overcome multiple barriers and maximize drug delivery to the target tumors, simultaneously limiting side effects. Since the first observation of the quantum tunneling phenomenon, many mul-tidisciplinary studies have offered quantum-inspired solutions to optimized tumor mapping and efficient nanodrug design. The property of a wave function to propagate through a potential barrier offer the capability of obtaining 3D surface profiles using imaging of individual atoms on the surface of a material. The application of quantum tunneling on a scanning tunneling microscope offers an exact surface roughness mapping of tumors and pharmaceutical particles. Critical elements to cancer nanotherapeutics apply the fractal theory and calculate the fractal dimension for efficient tumor surface imaging at the atomic level. This review study presents the latest biological approaches to cancer management based on fractal geometry.

Original language	English
Pages (from-to)	356-370
Number of pages	15
Journal	Current Medicinal Chemistry
Volume	30
Issue number	3
DOIs	https://doi.org/10.2174/0929867329666220801152347
Publication status	Published - 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Box-counting algorithm
cancer
chaos theory
drug delivery
fractal dimension
fractality
imaging da-ta
lacunarity
nanoparticles
pharmacokinetics
quantum tunneling
scanning tunneling microscope
succolarity

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10.2174/0929867329666220801152347

Cite this

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title = "The Fractal Viewpoint of Tumors and Nanoparticles",

abstract = "Even though the promising therapies against cancer are rapidly improved, the oncology patients population has seen exponential growth, placing cancer in 5th place among the ten deadliest diseases. Efficient drug delivery systems must overcome multiple barriers and maximize drug delivery to the target tumors, simultaneously limiting side effects. Since the first observation of the quantum tunneling phenomenon, many mul-tidisciplinary studies have offered quantum-inspired solutions to optimized tumor mapping and efficient nanodrug design. The property of a wave function to propagate through a potential barrier offer the capability of obtaining 3D surface profiles using imaging of individual atoms on the surface of a material. The application of quantum tunneling on a scanning tunneling microscope offers an exact surface roughness mapping of tumors and pharmaceutical particles. Critical elements to cancer nanotherapeutics apply the fractal theory and calculate the fractal dimension for efficient tumor surface imaging at the atomic level. This review study presents the latest biological approaches to cancer management based on fractal geometry.",

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doi = "10.2174/0929867329666220801152347",

language = "English",

volume = "30",

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AU - Alexiou, Athanasios

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AU - Chatzichronis, Stylianos

AU - Koulouris, Andreas

AU - Haranas, Ioannis

AU - Gkigkitzis, Ioannis

AU - Zouganelis, Georgios

AU - Mukerjee, Nobendu

AU - Maitra, Swastika

AU - Jha, Niraj Kumar

AU - Batiha, Gaber El Saber

AU - Kamal, Mohammad Amjad

AU - Nikolaou, Michail

AU - Ashraf, Ghulam Md

PY - 2023

Y1 - 2023

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AB - Even though the promising therapies against cancer are rapidly improved, the oncology patients population has seen exponential growth, placing cancer in 5th place among the ten deadliest diseases. Efficient drug delivery systems must overcome multiple barriers and maximize drug delivery to the target tumors, simultaneously limiting side effects. Since the first observation of the quantum tunneling phenomenon, many mul-tidisciplinary studies have offered quantum-inspired solutions to optimized tumor mapping and efficient nanodrug design. The property of a wave function to propagate through a potential barrier offer the capability of obtaining 3D surface profiles using imaging of individual atoms on the surface of a material. The application of quantum tunneling on a scanning tunneling microscope offers an exact surface roughness mapping of tumors and pharmaceutical particles. Critical elements to cancer nanotherapeutics apply the fractal theory and calculate the fractal dimension for efficient tumor surface imaging at the atomic level. This review study presents the latest biological approaches to cancer management based on fractal geometry.

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KW - cancer

KW - chaos theory

KW - drug delivery

KW - fractal dimension

KW - fractality

KW - imaging da-ta

KW - lacunarity

KW - nanoparticles

KW - pharmacokinetics

KW - quantum tunneling

KW - scanning tunneling microscope

KW - succolarity

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AN - SCOPUS:85144175909

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JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 3

ER -

The Fractal Viewpoint of Tumors and Nanoparticles

Abstract

UN SDGs

Keywords

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