The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning

Ashley Denmark; David Tien; Keith Wong; Amanda Chung; Jonathan Cachat; Jason Goodspeed; Chelsea Grimes; Marco Elegante; Christopher Suciu; Salem Elkhayat; Brett Bartels; Andrew Jackson; Michael Rosenberg; Kyung Min Chung; Hussain Badani; Ferdous Kadri; Sudipta Roy; Julia Tan; Siddharth Gaikwad; Adam Stewart; Ivan Zapolsky; Thomas Gilder; Allan V. Kalueff

doi:10.1016/j.bbr.2009.12.041

The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning

Ashley Denmark, David Tien, Keith Wong, Amanda Chung, Jonathan Cachat, Jason Goodspeed, Chelsea Grimes, Marco Elegante, Christopher Suciu, Salem Elkhayat, Brett Bartels, Andrew Jackson, Michael Rosenberg, Kyung Min Chung, Hussain Badani, Ferdous Kadri, Sudipta Roy, Julia Tan, Siddharth Gaikwad, Adam StewartIvan Zapolsky, Thomas Gilder, Allan V. Kalueff^*

^*Corresponding author for this work

Tulane University

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Stress induced by social defeat is a strong modifier of animal anxiety and depression-like phenotypes. Self-grooming is a common rodent behavior, and has an ordered cephalo-caudal progression from licking of the paws to head, body, genitals and tail. Acute stress is known to alter grooming activity levels and disrupt its patterning. Following 15-17 days of chronic social defeat stress, grooming behavior was analyzed in adult male C57BL/6J mice exhibiting either dominant or subordinate behavior. Our study showed that subordinate mice experience higher levels of anxiety and display disorganized patterning of their grooming behaviors, which emerges as a behavioral marker of chronic social stress. These findings indicate that chronic social stress modulates grooming behavior in mice, thus illustrating the importance of grooming phenotypes for neurobehavioral stress research.

Original language	English
Pages (from-to)	553-559
Number of pages	7
Journal	Behavioural Brain Research
Volume	208
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2009.12.041
Publication status	Published - 2 Apr 2010
Externally published	Yes

Keywords

Behavioral organization
Chronic social defeat
Grooming
Mice
Stress

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10.1016/j.bbr.2009.12.041

Cite this

Denmark, A., Tien, D., Wong, K., Chung, A., Cachat, J., Goodspeed, J., Grimes, C., Elegante, M., Suciu, C., Elkhayat, S., Bartels, B., Jackson, A., Rosenberg, M., Chung, K. M., Badani, H., Kadri, F., Roy, S., Tan, J., Gaikwad, S., ... Kalueff, A. V. (2010). The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning. Behavioural Brain Research, 208(2), 553-559. https://doi.org/10.1016/j.bbr.2009.12.041

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title = "The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning",

abstract = "Stress induced by social defeat is a strong modifier of animal anxiety and depression-like phenotypes. Self-grooming is a common rodent behavior, and has an ordered cephalo-caudal progression from licking of the paws to head, body, genitals and tail. Acute stress is known to alter grooming activity levels and disrupt its patterning. Following 15-17 days of chronic social defeat stress, grooming behavior was analyzed in adult male C57BL/6J mice exhibiting either dominant or subordinate behavior. Our study showed that subordinate mice experience higher levels of anxiety and display disorganized patterning of their grooming behaviors, which emerges as a behavioral marker of chronic social stress. These findings indicate that chronic social stress modulates grooming behavior in mice, thus illustrating the importance of grooming phenotypes for neurobehavioral stress research.",

keywords = "Behavioral organization, Chronic social defeat, Grooming, Mice, Stress",

author = "Ashley Denmark and David Tien and Keith Wong and Amanda Chung and Jonathan Cachat and Jason Goodspeed and Chelsea Grimes and Marco Elegante and Christopher Suciu and Salem Elkhayat and Brett Bartels and Andrew Jackson and Michael Rosenberg and Chung, \{Kyung Min\} and Hussain Badani and Ferdous Kadri and Sudipta Roy and Julia Tan and Siddharth Gaikwad and Adam Stewart and Ivan Zapolsky and Thomas Gilder and Kalueff, \{Allan V.\}",

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Denmark, A, Tien, D, Wong, K, Chung, A, Cachat, J, Goodspeed, J, Grimes, C, Elegante, M, Suciu, C, Elkhayat, S, Bartels, B, Jackson, A, Rosenberg, M, Chung, KM, Badani, H, Kadri, F, Roy, S, Tan, J, Gaikwad, S, Stewart, A, Zapolsky, I, Gilder, T & Kalueff, AV 2010, 'The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning', Behavioural Brain Research, vol. 208, no. 2, pp. 553-559. https://doi.org/10.1016/j.bbr.2009.12.041

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AU - Tien, David

AU - Wong, Keith

AU - Chung, Amanda

AU - Cachat, Jonathan

AU - Goodspeed, Jason

AU - Grimes, Chelsea

AU - Elegante, Marco

AU - Suciu, Christopher

AU - Elkhayat, Salem

AU - Bartels, Brett

AU - Jackson, Andrew

AU - Rosenberg, Michael

AU - Chung, Kyung Min

AU - Badani, Hussain

AU - Kadri, Ferdous

AU - Roy, Sudipta

AU - Tan, Julia

AU - Gaikwad, Siddharth

AU - Stewart, Adam

AU - Zapolsky, Ivan

AU - Gilder, Thomas

AU - Kalueff, Allan V.

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AB - Stress induced by social defeat is a strong modifier of animal anxiety and depression-like phenotypes. Self-grooming is a common rodent behavior, and has an ordered cephalo-caudal progression from licking of the paws to head, body, genitals and tail. Acute stress is known to alter grooming activity levels and disrupt its patterning. Following 15-17 days of chronic social defeat stress, grooming behavior was analyzed in adult male C57BL/6J mice exhibiting either dominant or subordinate behavior. Our study showed that subordinate mice experience higher levels of anxiety and display disorganized patterning of their grooming behaviors, which emerges as a behavioral marker of chronic social stress. These findings indicate that chronic social stress modulates grooming behavior in mice, thus illustrating the importance of grooming phenotypes for neurobehavioral stress research.

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KW - Grooming

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KW - Stress

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The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning

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Keywords

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