Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference

Xuan Xue; George Pasparakis; Nigel Halliday; Klaus Winzer; Steven M. Howdle; Christopher J. Cramphorn; Neil R. Cameron; Paul M. Gardner; Benjamin G. Davis; Francisco Fernández-Trillo; Cameron Alexander

doi:10.1002/anie.201103130

Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference

Xuan Xue
, George Pasparakis
, Nigel Halliday
, Klaus Winzer
, Steven M. Howdle
, Christopher J. Cramphorn
, Neil R. Cameron
, Paul M. Gardner
, Benjamin G. Davis^*
, Francisco Fernández-Trillo
, Cameron Alexander

^*Corresponding author for this work

University of Nottingham
Durham University
University of Oxford

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.

Original language	English
Pages (from-to)	9852-9856
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	42
DOIs	https://doi.org/10.1002/anie.201103130
Publication status	Published - 10 Oct 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 14 Life Below Water

Keywords

cell adhesion
luminescence
polymers
quorum sensing
therapeutics

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10.1002/anie.201103130

Cite this

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title = "Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference",

abstract = "Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.",

keywords = "cell adhesion, luminescence, polymers, quorum sensing, therapeutics",

author = "Xuan Xue and George Pasparakis and Nigel Halliday and Klaus Winzer and Howdle, \{Steven M.\} and Cramphorn, \{Christopher J.\} and Cameron, \{Neil R.\} and Gardner, \{Paul M.\} and Davis, \{Benjamin G.\} and Francisco Fern{\'a}ndez-Trillo and Cameron Alexander",

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doi = "10.1002/anie.201103130",

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T1 - Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference

AU - Xue, Xuan

AU - Pasparakis, George

AU - Halliday, Nigel

AU - Winzer, Klaus

AU - Howdle, Steven M.

AU - Cramphorn, Christopher J.

AU - Cameron, Neil R.

AU - Gardner, Paul M.

AU - Davis, Benjamin G.

AU - Fernández-Trillo, Francisco

AU - Alexander, Cameron

PY - 2011/10/10

Y1 - 2011/10/10

N2 - Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.

AB - Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.

KW - cell adhesion

KW - luminescence

KW - polymers

KW - quorum sensing

KW - therapeutics

UR - https://www.scopus.com/pages/publications/80053925905

U2 - 10.1002/anie.201103130

DO - 10.1002/anie.201103130

M3 - Article

C2 - 21922612

AN - SCOPUS:80053925905

SN - 1433-7851

VL - 50

SP - 9852

EP - 9856

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 42

ER -

Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference

Abstract

UN SDGs

Keywords

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