Synthesis of pyridine-based polyaminocarboxylic ligands bearing a thioalkyl anchor

Yi Lin; Alain Favre-Réguillon; Stéphane Pellet-Rostaing; Marc Lemaire

doi:10.1016/j.tetlet.2007.03.024

Synthesis of pyridine-based polyaminocarboxylic ligands bearing a thioalkyl anchor

Yi Lin
, Alain Favre-Réguillon
, Stéphane Pellet-Rostaing^*
, Marc Lemaire

^*Corresponding author for this work

Laboratoire de Catalyse et Synthèse Organique
Conservatoire national des arts et métiers

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A bicyclic tetraazatriacetic chelating agent containing a thioalkyl pendant group was prepared. Four synthetic routes have been investigated via a Mitsunobu reaction from 2,4-[bishydroxymethyl]-3-hydroxy-pyridine 1. Deprotection of trityl thioether compound 5c led to ligand 6c in 22% overall yield from the starting 3-hydroxypyridine.

Original language	English
Pages (from-to)	3463-3466
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	19
DOIs	https://doi.org/10.1016/j.tetlet.2007.03.024
Publication status	Published - 7 May 2007
Externally published	Yes

Keywords

Azamacrocycle
Mitsunobu reaction
PCTA
Thiol

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10.1016/j.tetlet.2007.03.024

Cite this

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title = "Synthesis of pyridine-based polyaminocarboxylic ligands bearing a thioalkyl anchor",

abstract = "A bicyclic tetraazatriacetic chelating agent containing a thioalkyl pendant group was prepared. Four synthetic routes have been investigated via a Mitsunobu reaction from 2,4-[bishydroxymethyl]-3-hydroxy-pyridine 1. Deprotection of trityl thioether compound 5c led to ligand 6c in 22\% overall yield from the starting 3-hydroxypyridine.",

keywords = "Azamacrocycle, Mitsunobu reaction, PCTA, Thiol",

author = "Yi Lin and Alain Favre-R{\'e}guillon and St{\'e}phane Pellet-Rostaing and Marc Lemaire",

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doi = "10.1016/j.tetlet.2007.03.024",

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journal = "Tetrahedron Letters",

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T1 - Synthesis of pyridine-based polyaminocarboxylic ligands bearing a thioalkyl anchor

AU - Lin, Yi

AU - Favre-Réguillon, Alain

AU - Pellet-Rostaing, Stéphane

AU - Lemaire, Marc

PY - 2007/5/7

Y1 - 2007/5/7

N2 - A bicyclic tetraazatriacetic chelating agent containing a thioalkyl pendant group was prepared. Four synthetic routes have been investigated via a Mitsunobu reaction from 2,4-[bishydroxymethyl]-3-hydroxy-pyridine 1. Deprotection of trityl thioether compound 5c led to ligand 6c in 22% overall yield from the starting 3-hydroxypyridine.

AB - A bicyclic tetraazatriacetic chelating agent containing a thioalkyl pendant group was prepared. Four synthetic routes have been investigated via a Mitsunobu reaction from 2,4-[bishydroxymethyl]-3-hydroxy-pyridine 1. Deprotection of trityl thioether compound 5c led to ligand 6c in 22% overall yield from the starting 3-hydroxypyridine.

KW - Azamacrocycle

KW - Mitsunobu reaction

KW - PCTA

KW - Thiol

UR - https://www.scopus.com/pages/publications/34247274095

U2 - 10.1016/j.tetlet.2007.03.024

DO - 10.1016/j.tetlet.2007.03.024

M3 - Article

AN - SCOPUS:34247274095

SN - 0040-4039

VL - 48

SP - 3463

EP - 3466

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 19

ER -

Synthesis of pyridine-based polyaminocarboxylic ligands bearing a thioalkyl anchor

Abstract

Keywords

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