Synthesis of cyclophospho-glucoses and glucitols

E. J. Amigues; M. L. Greenberg; S. Ju; Y. Chen; M. E. Migaud

doi:10.1016/j.tet.2007.07.027

Synthesis of cyclophospho-glucoses and glucitols

E. J. Amigues, M. L. Greenberg, S. Ju, Y. Chen, M. E. Migaud^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The syntheses of cyclophosphodiesters of 5-C-(hydroxymethyl)-hexoses and hexitols and of 6-C-(hydroxymethyl)-hexoses are reported, along with that of 6-deoxy-gluco-heptose 7-phosphate. These compounds proved to be reasonable substrate mimics and show inhibitory activity against human d-myo-inositol 3-phosphate synthase.

Original language	English
Pages (from-to)	10042-10053
Number of pages	12
Journal	Tetrahedron
Volume	63
Issue number	40
DOIs	https://doi.org/10.1016/j.tet.2007.07.027
Publication status	Published - 1 Oct 2007
Externally published	Yes

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10.1016/j.tet.2007.07.027

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title = "Synthesis of cyclophospho-glucoses and glucitols",

abstract = "The syntheses of cyclophosphodiesters of 5-C-(hydroxymethyl)-hexoses and hexitols and of 6-C-(hydroxymethyl)-hexoses are reported, along with that of 6-deoxy-gluco-heptose 7-phosphate. These compounds proved to be reasonable substrate mimics and show inhibitory activity against human d-myo-inositol 3-phosphate synthase.",

author = "Amigues, \{E. J.\} and Greenberg, \{M. L.\} and S. Ju and Y. Chen and Migaud, \{M. E.\}",

note = "Funding Information: We wish to thank the EPSRC for funding E.J.A. Ph.D. studentship.",

year = "2007",

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language = "English",

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journal = "Tetrahedron",

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TY - JOUR

T1 - Synthesis of cyclophospho-glucoses and glucitols

AU - Amigues, E. J.

AU - Greenberg, M. L.

AU - Ju, S.

AU - Chen, Y.

AU - Migaud, M. E.

N1 - Funding Information: We wish to thank the EPSRC for funding E.J.A. Ph.D. studentship.

PY - 2007/10/1

Y1 - 2007/10/1

N2 - The syntheses of cyclophosphodiesters of 5-C-(hydroxymethyl)-hexoses and hexitols and of 6-C-(hydroxymethyl)-hexoses are reported, along with that of 6-deoxy-gluco-heptose 7-phosphate. These compounds proved to be reasonable substrate mimics and show inhibitory activity against human d-myo-inositol 3-phosphate synthase.

AB - The syntheses of cyclophosphodiesters of 5-C-(hydroxymethyl)-hexoses and hexitols and of 6-C-(hydroxymethyl)-hexoses are reported, along with that of 6-deoxy-gluco-heptose 7-phosphate. These compounds proved to be reasonable substrate mimics and show inhibitory activity against human d-myo-inositol 3-phosphate synthase.

UR - https://www.scopus.com/pages/publications/34547939881

U2 - 10.1016/j.tet.2007.07.027

DO - 10.1016/j.tet.2007.07.027

M3 - Article

AN - SCOPUS:34547939881

SN - 0040-4020

VL - 63

SP - 10042

EP - 10053

JO - Tetrahedron

JF - Tetrahedron

IS - 40

ER -

Synthesis of cyclophospho-glucoses and glucitols

Abstract

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