Synthesis and cytotoxicity studies of new cryptophycin analogues

Lu Liu Wen; Cun Zhang Jian; Qin Jiang Fa; Lei Fu

doi:10.1002/ardp.200900067

Synthesis and cytotoxicity studies of new cryptophycin analogues

Lu Liu Wen, Cun Zhang Jian, Qin Jiang Fa, Lei Fu

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC₅₀ values in the μM-range, and compound 4 was more effective than compound 3 in most assays studied.

Original language	English
Pages (from-to)	577-583
Number of pages	7
Journal	Archiv der Pharmazie
Volume	342
Issue number	10
DOIs	https://doi.org/10.1002/ardp.200900067
Publication status	Published - Oct 2009
Externally published	Yes

Keywords

Anticancer
Cryptophycin
Cytotoxicity
Synthesis
Taxol

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10.1002/ardp.200900067

Cite this

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title = "Synthesis and cytotoxicity studies of new cryptophycin analogues",

abstract = "Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC50 values in the μM-range, and compound 4 was more effective than compound 3 in most assays studied.",

keywords = "Anticancer, Cryptophycin, Cytotoxicity, Synthesis, Taxol",

author = "Wen, \{Lu Liu\} and Jian, \{Cun Zhang\} and Fa, \{Qin Jiang\} and Lei Fu",

year = "2009",

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AU - Wen, Lu Liu

AU - Jian, Cun Zhang

AU - Fa, Qin Jiang

AU - Fu, Lei

PY - 2009/10

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N2 - Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC50 values in the μM-range, and compound 4 was more effective than compound 3 in most assays studied.

AB - Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC50 values in the μM-range, and compound 4 was more effective than compound 3 in most assays studied.

KW - Anticancer

KW - Cryptophycin

KW - Cytotoxicity

KW - Synthesis

KW - Taxol

UR - https://www.scopus.com/pages/publications/70349637316

U2 - 10.1002/ardp.200900067

DO - 10.1002/ardp.200900067

M3 - Article

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AN - SCOPUS:70349637316

SN - 0365-6233

VL - 342

SP - 577

EP - 583

JO - Archiv der Pharmazie

JF - Archiv der Pharmazie

IS - 10

ER -

Synthesis and cytotoxicity studies of new cryptophycin analogues

Abstract

Keywords

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