Synthesis and biological evaluation of novel selenonucleosides

Yao Chen; Yingdan Peng; Jiancun Zhang; Lei Fu

doi:10.1080/15257770802088803

Synthesis and biological evaluation of novel selenonucleosides

Yao Chen
, Yingdan Peng
, Jiancun Zhang
, Lei Fu^*

^*Corresponding author for this work

Shanghai Jiao Tong University
CAS - Guangzhou Institute of Biomedicine and Health

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents.

Original language	English
Pages (from-to)	1001-1008
Number of pages	8
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	27
Issue number	8
DOIs	https://doi.org/10.1080/15257770802088803
Publication status	Published - Aug 2008
Externally published	Yes

Keywords

1,4-oxaselenane
Biological evaluation
Selenonucleoside
Synthesis

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10.1080/15257770802088803

Cite this

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title = "Synthesis and biological evaluation of novel selenonucleosides",

abstract = "A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents.",

keywords = "1,4-oxaselenane, Biological evaluation, Selenonucleoside, Synthesis",

author = "Yao Chen and Yingdan Peng and Jiancun Zhang and Lei Fu",

note = "Funding Information: Received 6 November 2007; accepted 27 February 2008. This research was financially supported by an Innovation Grant (08ZZ12) from the Shanghai Municipal Education Commission. Address correspondence to Lei Fu, School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, P. R. China; E-mail: leifu@sjtu.edu.cn or Jiancun Zhang, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou510663, P. R. China E-mail: zhang jiancun@ gibh.ac.cn.",

year = "2008",

month = aug,

doi = "10.1080/15257770802088803",

language = "English",

volume = "27",

pages = "1001--1008",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

issn = "1525-7770",

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T1 - Synthesis and biological evaluation of novel selenonucleosides

AU - Chen, Yao

AU - Peng, Yingdan

AU - Zhang, Jiancun

AU - Fu, Lei

N1 - Funding Information: Received 6 November 2007; accepted 27 February 2008. This research was financially supported by an Innovation Grant (08ZZ12) from the Shanghai Municipal Education Commission. Address correspondence to Lei Fu, School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, P. R. China; E-mail: leifu@sjtu.edu.cn or Jiancun Zhang, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou510663, P. R. China E-mail: zhang jiancun@ gibh.ac.cn.

PY - 2008/8

Y1 - 2008/8

N2 - A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents.

AB - A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents.

KW - 1,4-oxaselenane

KW - Biological evaluation

KW - Selenonucleoside

KW - Synthesis

UR - https://www.scopus.com/pages/publications/49549121105

U2 - 10.1080/15257770802088803

DO - 10.1080/15257770802088803

M3 - Article

C2 - 18696368

AN - SCOPUS:49549121105

SN - 1525-7770

VL - 27

SP - 1001

EP - 1008

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 8

ER -

Synthesis and biological evaluation of novel selenonucleosides

Abstract

Keywords

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