Synthesis and antimicrobial evaluation of new benzofuran derivatives

Xizhen Jiang; Wenlu Liu; Wei Zhang; Faqin Jiang; Zhe Gao; Hao Zhuang; Lei Fu

doi:10.1016/j.ejmech.2011.04.053

Synthesis and antimicrobial evaluation of new benzofuran derivatives

Xizhen Jiang
, Wenlu Liu
, Wei Zhang
, Faqin Jiang
, Zhe Gao
, Hao Zhuang
, Lei Fu^*

^*Corresponding author for this work

Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC₈₀ = 0.39-3.12 μg/mL), which were better than the control drugs.

Original language	English
Pages (from-to)	3526-3530
Number of pages	5
Journal	European Journal of Medicinal Chemistry
Volume	46
Issue number	8
DOIs	https://doi.org/10.1016/j.ejmech.2011.04.053
Publication status	Published - Aug 2011
Externally published	Yes

Keywords

Anti-microorganism
Benzofuran
Stilbenoid
Synthesis

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10.1016/j.ejmech.2011.04.053

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@article{40823952d3064fff877489874b13f09b,

title = "Synthesis and antimicrobial evaluation of new benzofuran derivatives",

abstract = "Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC80 = 0.39-3.12 μg/mL), which were better than the control drugs.",

keywords = "Anti-microorganism, Benzofuran, Stilbenoid, Synthesis",

author = "Xizhen Jiang and Wenlu Liu and Wei Zhang and Faqin Jiang and Zhe Gao and Hao Zhuang and Lei Fu",

note = "Funding Information: We thanked the National Comprehensive Technology Platforms for Innovative Drug R\&D, 2009ZX09301-007 for the financial support. We also thanked Zhao{\textquoteright}s Laboratory for the supplies about the MIC 80 test.",

year = "2011",

month = aug,

doi = "10.1016/j.ejmech.2011.04.053",

language = "English",

volume = "46",

pages = "3526--3530",

journal = "European Journal of Medicinal Chemistry",

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T1 - Synthesis and antimicrobial evaluation of new benzofuran derivatives

AU - Jiang, Xizhen

AU - Liu, Wenlu

AU - Zhang, Wei

AU - Jiang, Faqin

AU - Gao, Zhe

AU - Zhuang, Hao

AU - Fu, Lei

N1 - Funding Information: We thanked the National Comprehensive Technology Platforms for Innovative Drug R&D, 2009ZX09301-007 for the financial support. We also thanked Zhao’s Laboratory for the supplies about the MIC 80 test.

PY - 2011/8

Y1 - 2011/8

N2 - Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC80 = 0.39-3.12 μg/mL), which were better than the control drugs.

AB - Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC80 = 0.39-3.12 μg/mL), which were better than the control drugs.

KW - Anti-microorganism

KW - Benzofuran

KW - Stilbenoid

KW - Synthesis

UR - https://www.scopus.com/pages/publications/79958275800

U2 - 10.1016/j.ejmech.2011.04.053

DO - 10.1016/j.ejmech.2011.04.053

M3 - Article

C2 - 21570749

AN - SCOPUS:79958275800

SN - 0223-5234

VL - 46

SP - 3526

EP - 3530

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 8

ER -

Synthesis and antimicrobial evaluation of new benzofuran derivatives

Abstract

Keywords

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