Surface Coordination of Black Phosphorus with Modified Cisplatin

Jianing Zhang; Yue Ma; Kuan Hu; Yuan Feng; Si Chen; Xiaoyang Yang; Jacky Fong-Chuen Loo; Han Zhang; Feng Yin; Zigang Li

doi:10.1021/acs.bioconjchem.9b00128

Surface Coordination of Black Phosphorus with Modified Cisplatin

Jianing Zhang
, Yue Ma
, Kuan Hu
, Yuan Feng
, Si Chen
, Xiaoyang Yang
, Jacky Fong-Chuen Loo
, Han Zhang
, Feng Yin^*
, Zigang Li

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Black phosphorus (BP) is a two-dimensional (2D) nanomaterial with high charge-carrier mobility, a tunable direct bandgap, and a unique in-plane anisotropic structure; however, the easiness of BP oxidation into P_xO_y species in ambient conditions largely limits its applications. In this study, modified cisplatin-Pt-NO₃ [Pt(NH₃)₂(NO₃)₂] is used for surface coordination with BP nanosheets to generate Pt@BP, which maintains the surface morphology and properties of BP nanosheets for more than 24 h in ambient conditions. In addition, Pt@BP interacts with DNA both in vitro and in cell. Pt@BP shows a good cellular uptake rate and significantly increases the drug sensitivity of cisplatin-resistant cancer cell lines (A2780 and HepG2) compared with unmodified cisplatin. Our study is the first attempt to stabilize bare BP with cationic cisplatin species, and the generated Pt@BP could be used for potential synergistic photothermal/chemotherapy of cisplatin-resistant cancer.

Original language	English
Pages (from-to)	1658-1664
Number of pages	7
Journal	Bioconjugate Chemistry
Volume	30
Issue number	6
DOIs	https://doi.org/10.1021/acs.bioconjchem.9b00128
Publication status	Published - 19 Jun 2019
Externally published	Yes

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10.1021/acs.bioconjchem.9b00128

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@article{2504553265bd401eab21882d4e66ba52,

title = "Surface Coordination of Black Phosphorus with Modified Cisplatin",

abstract = "Black phosphorus (BP) is a two-dimensional (2D) nanomaterial with high charge-carrier mobility, a tunable direct bandgap, and a unique in-plane anisotropic structure; however, the easiness of BP oxidation into PxOy species in ambient conditions largely limits its applications. In this study, modified cisplatin-Pt-NO3 [Pt(NH3)2(NO3)2] is used for surface coordination with BP nanosheets to generate Pt@BP, which maintains the surface morphology and properties of BP nanosheets for more than 24 h in ambient conditions. In addition, Pt@BP interacts with DNA both in vitro and in cell. Pt@BP shows a good cellular uptake rate and significantly increases the drug sensitivity of cisplatin-resistant cancer cell lines (A2780 and HepG2) compared with unmodified cisplatin. Our study is the first attempt to stabilize bare BP with cationic cisplatin species, and the generated Pt@BP could be used for potential synergistic photothermal/chemotherapy of cisplatin-resistant cancer.",

author = "Jianing Zhang and Yue Ma and Kuan Hu and Yuan Feng and Si Chen and Xiaoyang Yang and \{Fong-Chuen Loo\}, Jacky and Han Zhang and Feng Yin and Zigang Li",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = jun,

day = "19",

doi = "10.1021/acs.bioconjchem.9b00128",

language = "English",

volume = "30",

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journal = "Bioconjugate Chemistry",

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TY - JOUR

T1 - Surface Coordination of Black Phosphorus with Modified Cisplatin

AU - Zhang, Jianing

AU - Ma, Yue

AU - Hu, Kuan

AU - Feng, Yuan

AU - Chen, Si

AU - Yang, Xiaoyang

AU - Fong-Chuen Loo, Jacky

AU - Zhang, Han

AU - Yin, Feng

AU - Li, Zigang

PY - 2019/6/19

Y1 - 2019/6/19

N2 - Black phosphorus (BP) is a two-dimensional (2D) nanomaterial with high charge-carrier mobility, a tunable direct bandgap, and a unique in-plane anisotropic structure; however, the easiness of BP oxidation into PxOy species in ambient conditions largely limits its applications. In this study, modified cisplatin-Pt-NO3 [Pt(NH3)2(NO3)2] is used for surface coordination with BP nanosheets to generate Pt@BP, which maintains the surface morphology and properties of BP nanosheets for more than 24 h in ambient conditions. In addition, Pt@BP interacts with DNA both in vitro and in cell. Pt@BP shows a good cellular uptake rate and significantly increases the drug sensitivity of cisplatin-resistant cancer cell lines (A2780 and HepG2) compared with unmodified cisplatin. Our study is the first attempt to stabilize bare BP with cationic cisplatin species, and the generated Pt@BP could be used for potential synergistic photothermal/chemotherapy of cisplatin-resistant cancer.

AB - Black phosphorus (BP) is a two-dimensional (2D) nanomaterial with high charge-carrier mobility, a tunable direct bandgap, and a unique in-plane anisotropic structure; however, the easiness of BP oxidation into PxOy species in ambient conditions largely limits its applications. In this study, modified cisplatin-Pt-NO3 [Pt(NH3)2(NO3)2] is used for surface coordination with BP nanosheets to generate Pt@BP, which maintains the surface morphology and properties of BP nanosheets for more than 24 h in ambient conditions. In addition, Pt@BP interacts with DNA both in vitro and in cell. Pt@BP shows a good cellular uptake rate and significantly increases the drug sensitivity of cisplatin-resistant cancer cell lines (A2780 and HepG2) compared with unmodified cisplatin. Our study is the first attempt to stabilize bare BP with cationic cisplatin species, and the generated Pt@BP could be used for potential synergistic photothermal/chemotherapy of cisplatin-resistant cancer.

UR - https://www.scopus.com/pages/publications/85067449861

U2 - 10.1021/acs.bioconjchem.9b00128

DO - 10.1021/acs.bioconjchem.9b00128

M3 - Article

C2 - 31070357

AN - SCOPUS:85067449861

SN - 1043-1802

VL - 30

SP - 1658

EP - 1664

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

IS - 6

ER -

Surface Coordination of Black Phosphorus with Modified Cisplatin

Abstract

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