[ 18F]Si-RiboRGD: From design and synthesis to the imaging of α vβ 3 integrins in melanoma tumors

Eric Amigues; Jürgen Schulz; Magali Szlosek-Pinaud; Philippe Fernandez; Sandrine Silvente-Poirot; Séverine Brillouet; Frédéric Courbon; Eric Fouquet

doi:10.1002/cplu.201200022

[ ¹⁸F]Si-RiboRGD: From design and synthesis to the imaging of α _vβ ₃ integrins in melanoma tumors

Eric Amigues
, Jürgen Schulz
, Magali Szlosek-Pinaud^*
, Philippe Fernandez
, Sandrine Silvente-Poirot
, Séverine Brillouet
, Frédéric Courbon
, Eric Fouquet

^*Corresponding author for this work

Université de Bordeaux
Insitut Claudius Regaud

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The winning combination: A new and promising ¹⁸F-labeled RGD derivative has been efficiently prepared by exploiting the advantages of "click" chemistry and a one-step labeling protocol where a silicon-based building blocks was used (see figure). This derivative could be a new starting point for improved visualization of α _vβ ₃-positive tumors by positron emission tomography.

Original language	English
Pages (from-to)	345-349
Number of pages	5
Journal	ChemPlusChem
Volume	77
Issue number	5
DOIs	https://doi.org/10.1002/cplu.201200022
Publication status	Published - May 2012
Externally published	Yes

Keywords

Click chemistry
F-labeling
PET imaging
RGD peptides
Silicon

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10.1002/cplu.201200022

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AU - Amigues, Eric

AU - Schulz, Jürgen

AU - Szlosek-Pinaud, Magali

AU - Fernandez, Philippe

AU - Silvente-Poirot, Sandrine

AU - Brillouet, Séverine

AU - Courbon, Frédéric

AU - Fouquet, Eric

PY - 2012/5

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AB - The winning combination: A new and promising 18F-labeled RGD derivative has been efficiently prepared by exploiting the advantages of "click" chemistry and a one-step labeling protocol where a silicon-based building blocks was used (see figure). This derivative could be a new starting point for improved visualization of α vβ 3-positive tumors by positron emission tomography.

KW - Click chemistry

KW - F-labeling

KW - PET imaging

KW - RGD peptides

KW - Silicon

UR - https://www.scopus.com/pages/publications/84863652990

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[ ¹⁸F]Si-RiboRGD: From design and synthesis to the imaging of α _vβ ₃ integrins in melanoma tumors

Abstract

Keywords

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