Stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate by soluble, recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase

Nicholas P. Crouch; Robert M. Adlington; Jack E. Baldwin; Meng Huee Lee; Colin H. MacKinnon; Diana R. Paul

doi:10.1016/S0040-4020(97)00690-X

Stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate by soluble, recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase

Nicholas P. Crouch^*
, Robert M. Adlington
, Jack E. Baldwin
, Meng Huee Lee
, Colin H. MacKinnon
, Diana R. Paul

^*Corresponding author for this work

University of Oxford

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate catalysed by the enzyme 4-hydroxyphenylpyruvate dioxygenase is described.

Original language	English
Pages (from-to)	10827-10840
Number of pages	14
Journal	Tetrahedron
Volume	53
Issue number	31
DOIs	https://doi.org/10.1016/S0040-4020(97)00690-X
Publication status	Published - 4 Aug 1997
Externally published	Yes

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10.1016/S0040-4020(97)00690-X

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@article{11f6b73a039a4bada77c34f373f00601,

title = "Stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate by soluble, recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase",

abstract = "The stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate catalysed by the enzyme 4-hydroxyphenylpyruvate dioxygenase is described.",

author = "Crouch, \{Nicholas P.\} and Adlington, \{Robert M.\} and Baldwin, \{Jack E.\} and Lee, \{Meng Huee\} and MacKinnon, \{Colin H.\} and Paul, \{Diana R.\}",

note = "Funding Information: We thank the EPSRC for a grant (to CHM) and the British Council for an Overseas Research studentship (to MHL). We thank also Prof. R. A. Pascal, Princeton University, USA, for help in the early stages of our work, Dr Y. Fujishima and Mr J.P.N. Pitt for assistance with protein purification, Dr A. C. Willis for peptide sequencing, Dr. G. J. Pritchard for help with the synthetic chemistry and Dr Z. H. Zhang for assistance in the cloning of mammalian 4-HPPD.",

year = "1997",

month = aug,

day = "4",

doi = "10.1016/S0040-4020(97)00690-X",

language = "English",

volume = "53",

pages = "10827--10840",

journal = "Tetrahedron",

issn = "0040-4020",

number = "31",

}

TY - JOUR

T1 - Stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate by soluble, recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase

AU - Crouch, Nicholas P.

AU - Adlington, Robert M.

AU - Baldwin, Jack E.

AU - Lee, Meng Huee

AU - MacKinnon, Colin H.

AU - Paul, Diana R.

N1 - Funding Information: We thank the EPSRC for a grant (to CHM) and the British Council for an Overseas Research studentship (to MHL). We thank also Prof. R. A. Pascal, Princeton University, USA, for help in the early stages of our work, Dr Y. Fujishima and Mr J.P.N. Pitt for assistance with protein purification, Dr A. C. Willis for peptide sequencing, Dr. G. J. Pritchard for help with the synthetic chemistry and Dr Z. H. Zhang for assistance in the cloning of mammalian 4-HPPD.

PY - 1997/8/4

Y1 - 1997/8/4

N2 - The stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate catalysed by the enzyme 4-hydroxyphenylpyruvate dioxygenase is described.

AB - The stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate catalysed by the enzyme 4-hydroxyphenylpyruvate dioxygenase is described.

UR - https://www.scopus.com/pages/publications/0030839644

U2 - 10.1016/S0040-4020(97)00690-X

DO - 10.1016/S0040-4020(97)00690-X

M3 - Article

AN - SCOPUS:0030839644

SN - 0040-4020

VL - 53

SP - 10827

EP - 10840

JO - Tetrahedron

JF - Tetrahedron

IS - 31

ER -

Stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate by soluble, recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase

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