Role of splice variants of Gtf2i, a transcription factor localizing at postsynaptic sites, and its relation to neuropsychiatric diseases

Yoshinori Shirai; Weidong Li; Tatsuo Suzuki

doi:10.3390/ijms18020411

Role of splice variants of Gtf2i, a transcription factor localizing at postsynaptic sites, and its relation to neuropsychiatric diseases

Yoshinori Shirai
, Weidong Li
, Tatsuo Suzuki^*

^*Corresponding author for this work

Shinshu University
Shanghai Jiao Tong University

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

We previously reported that various mRNAs were associated with postsynaptic density (PSD) purified from rat forebrain. Among the thousands of PSD-associated mRNAs, we highlight the biology of the general transcription factor II-I (Gtf2i) mRNA, focusing on the significance of its versatile splicing for targeting its own mRNA into dendrites, regulation of translation, and the effects of Gtf2i expression level as well as its relationship with neuropsychiatric disorders.

Original language	English
Article number	411
Journal	International Journal of Molecular Sciences
Volume	18
Issue number	2
DOIs	https://doi.org/10.3390/ijms18020411
Publication status	Published - 15 Feb 2017
Externally published	Yes

Keywords

5 UTR
Alternative splicing
Local protein synthesis
Neuropsychiatric disorders
Postsynaptic density
Synapse
Synaptic plasticity
Transcription factor

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10.3390/ijms18020411

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title = "Role of splice variants of Gtf2i, a transcription factor localizing at postsynaptic sites, and its relation to neuropsychiatric diseases",

abstract = "We previously reported that various mRNAs were associated with postsynaptic density (PSD) purified from rat forebrain. Among the thousands of PSD-associated mRNAs, we highlight the biology of the general transcription factor II-I (Gtf2i) mRNA, focusing on the significance of its versatile splicing for targeting its own mRNA into dendrites, regulation of translation, and the effects of Gtf2i expression level as well as its relationship with neuropsychiatric disorders.",

keywords = "5 UTR, Alternative splicing, Local protein synthesis, Neuropsychiatric disorders, Postsynaptic density, Synapse, Synaptic plasticity, Transcription factor",

author = "Yoshinori Shirai and Weidong Li and Tatsuo Suzuki",

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T1 - Role of splice variants of Gtf2i, a transcription factor localizing at postsynaptic sites, and its relation to neuropsychiatric diseases

AU - Shirai, Yoshinori

AU - Li, Weidong

AU - Suzuki, Tatsuo

PY - 2017/2/15

Y1 - 2017/2/15

N2 - We previously reported that various mRNAs were associated with postsynaptic density (PSD) purified from rat forebrain. Among the thousands of PSD-associated mRNAs, we highlight the biology of the general transcription factor II-I (Gtf2i) mRNA, focusing on the significance of its versatile splicing for targeting its own mRNA into dendrites, regulation of translation, and the effects of Gtf2i expression level as well as its relationship with neuropsychiatric disorders.

AB - We previously reported that various mRNAs were associated with postsynaptic density (PSD) purified from rat forebrain. Among the thousands of PSD-associated mRNAs, we highlight the biology of the general transcription factor II-I (Gtf2i) mRNA, focusing on the significance of its versatile splicing for targeting its own mRNA into dendrites, regulation of translation, and the effects of Gtf2i expression level as well as its relationship with neuropsychiatric disorders.

KW - 5 UTR

KW - Alternative splicing

KW - Local protein synthesis

KW - Neuropsychiatric disorders

KW - Postsynaptic density

KW - Synapse

KW - Synaptic plasticity

KW - Transcription factor

UR - https://www.scopus.com/pages/publications/85013080619

U2 - 10.3390/ijms18020411

DO - 10.3390/ijms18020411

M3 - Review article

C2 - 28212274

AN - SCOPUS:85013080619

SN - 1661-6596

VL - 18

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 2

M1 - 411

ER -

Role of splice variants of Gtf2i, a transcription factor localizing at postsynaptic sites, and its relation to neuropsychiatric diseases

Abstract

Keywords

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