Reversing Neurodevelopmental Disorders in Adults

Dan Ehninger; Weidong Li; Kevin Fox; Michael P. Stryker; Alcino J. Silva

doi:10.1016/j.neuron.2008.12.007

Reversing Neurodevelopmental Disorders in Adults

Dan Ehninger
, Weidong Li
, Kevin Fox
, Michael P. Stryker
, Alcino J. Silva^*

^*Corresponding author for this work

University of California at Los Angeles
Cardiff University
University of California at San Francisco

Research output: Contribution to journal › Review article › peer-review

163 Citations (Scopus)

Abstract

Abnormalities in brain development, thought to be irreversible in adults, have long been assumed to underlie the neurological and psychiatric symptoms associated with neurodevelopmental disorders. Surprisingly, a number of recent animal model studies of neurodevelopmental disorders demonstrate that reversing the underlying molecular deficits can result in substantial improvements in function even if treatments are started in adulthood. These findings mark a paradigmatic change in the way we understand and envision treating neurodevelopmental disorders.

Original language	English
Pages (from-to)	950-960
Number of pages	11
Journal	Neuron
Volume	60
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2008.12.007
Publication status	Published - 26 Dec 2008
Externally published	Yes

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10.1016/j.neuron.2008.12.007

Cite this

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title = "Reversing Neurodevelopmental Disorders in Adults",

abstract = "Abnormalities in brain development, thought to be irreversible in adults, have long been assumed to underlie the neurological and psychiatric symptoms associated with neurodevelopmental disorders. Surprisingly, a number of recent animal model studies of neurodevelopmental disorders demonstrate that reversing the underlying molecular deficits can result in substantial improvements in function even if treatments are started in adulthood. These findings mark a paradigmatic change in the way we understand and envision treating neurodevelopmental disorders.",

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AU - Stryker, Michael P.

AU - Silva, Alcino J.

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AB - Abnormalities in brain development, thought to be irreversible in adults, have long been assumed to underlie the neurological and psychiatric symptoms associated with neurodevelopmental disorders. Surprisingly, a number of recent animal model studies of neurodevelopmental disorders demonstrate that reversing the underlying molecular deficits can result in substantial improvements in function even if treatments are started in adulthood. These findings mark a paradigmatic change in the way we understand and envision treating neurodevelopmental disorders.

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DO - 10.1016/j.neuron.2008.12.007

M3 - Review article

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Reversing Neurodevelopmental Disorders in Adults

Abstract

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