TY - JOUR
T1 - Rethinking the Role of DISC1 in CNS Function
T2 - Translational Cross-Taxon Insights From Rodent and Zebrafish Models
AU - Volgin, Andrey D.
AU - Cheresiz, Sergey V.
AU - Chizhova, Nadezhda D.
AU - Smirnova, Kristina V.
AU - Doroshkov, Alexey V.
AU - Galstya, David S.
AU - Abreu, Murilo S.de
AU - Strekalova, Tatyana
AU - Lipina, Tatiana
AU - Pletnikov, Mikhail
AU - Yang, Longen
AU - Lim, Lee Wei
AU - Stewart, Adam Michael
AU - Amstislavskaya, Tamara G.
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© 2025 The Author(s). Published by IMR Press.
PY - 2025/9/25
Y1 - 2025/9/25
N2 - Encoding a key 'hub' scaffolding protein, the 'Disrupted-In-Schizophrenia-1' (DISC1) gene has been strongly implicated in brain development and functions. Genetic variance in this gene is associated with major neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. DISC1 is abundantly expressed in the brain of humans and various model organisms. Here, we discuss currently available animal models of DISC1-related brain deficits and their clinical relevance. We focus on evolutionarily conserved (shared) mechanisms and species-specific phenotypes, especially in newly developed zebrafish (Danio rerio) models, to better understand the uniquely complex role of DISC1 in the molecular pathogenesis of neurobehavioral abnormalities relevant to human neuropsychiatric disorders.
AB - Encoding a key 'hub' scaffolding protein, the 'Disrupted-In-Schizophrenia-1' (DISC1) gene has been strongly implicated in brain development and functions. Genetic variance in this gene is associated with major neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. DISC1 is abundantly expressed in the brain of humans and various model organisms. Here, we discuss currently available animal models of DISC1-related brain deficits and their clinical relevance. We focus on evolutionarily conserved (shared) mechanisms and species-specific phenotypes, especially in newly developed zebrafish (Danio rerio) models, to better understand the uniquely complex role of DISC1 in the molecular pathogenesis of neurobehavioral abnormalities relevant to human neuropsychiatric disorders.
KW - DISC1
KW - animal models
KW - behavior
KW - neurogenesis
KW - neuropsychiatric disorders
KW - zebrafish
UR - https://www.scopus.com/pages/publications/105018398404
U2 - 10.31083/JIN43162
DO - 10.31083/JIN43162
M3 - Review article
C2 - 41074414
AN - SCOPUS:105018398404
SN - 0219-6352
VL - 24
SP - 43162
JO - Journal of Integrative Neuroscience
JF - Journal of Integrative Neuroscience
IS - 9
ER -