Quinoxaline-2,3-diones: Potential D-amino acid oxidase (DAAO) inhibitors

Dongsheng Xie; Yanchao Wang; Jin Xie; Jun Lu; Junjun Cui; Man Zhang; Lei Fu; Yongxiang Wang

doi:10.1007/s00044-014-1068-z

Quinoxaline-2,3-diones: Potential D-amino acid oxidase (DAAO) inhibitors

Dongsheng Xie
, Yanchao Wang
, Jin Xie
, Jun Lu
, Junjun Cui
, Man Zhang
, Lei Fu^*
, Yongxiang Wang

^*Corresponding author for this work

Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

A family of quinoxaline-2,3-diones was prepared and evaluated to exhibit D-amino acid oxidase (DAAO) inhibitory activities with IC₅₀ values ranging from 0.6 to 15 μM in vitro. SAR analysis revealed their binding modes with DAAO and provided an important clue for further design of highly potent DAAO inhibitors with novel structures.

Original language	English
Pages (from-to)	4977-4989
Number of pages	13
Journal	Medicinal Chemistry Research
Volume	23
Issue number	11
DOIs	https://doi.org/10.1007/s00044-014-1068-z
Publication status	Published - Nov 2014
Externally published	Yes

Keywords

D-Amino acid oxidase
DAAO
DAAO inhibitors
Quinoxaline-2,3-diones

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10.1007/s00044-014-1068-z

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abstract = "A family of quinoxaline-2,3-diones was prepared and evaluated to exhibit D-amino acid oxidase (DAAO) inhibitory activities with IC50 values ranging from 0.6 to 15 μM in vitro. SAR analysis revealed their binding modes with DAAO and provided an important clue for further design of highly potent DAAO inhibitors with novel structures.",

keywords = "D-Amino acid oxidase, DAAO, DAAO inhibitors, Quinoxaline-2,3-diones",

author = "Dongsheng Xie and Yanchao Wang and Jin Xie and Jun Lu and Junjun Cui and Man Zhang and Lei Fu and Yongxiang Wang",

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T2 - Potential D-amino acid oxidase (DAAO) inhibitors

AU - Xie, Dongsheng

AU - Wang, Yanchao

AU - Xie, Jin

AU - Lu, Jun

AU - Cui, Junjun

AU - Zhang, Man

AU - Fu, Lei

AU - Wang, Yongxiang

N1 - Publisher Copyright: © Springer Science+Business Media New York 2014.

PY - 2014/11

Y1 - 2014/11

N2 - A family of quinoxaline-2,3-diones was prepared and evaluated to exhibit D-amino acid oxidase (DAAO) inhibitory activities with IC50 values ranging from 0.6 to 15 μM in vitro. SAR analysis revealed their binding modes with DAAO and provided an important clue for further design of highly potent DAAO inhibitors with novel structures.

AB - A family of quinoxaline-2,3-diones was prepared and evaluated to exhibit D-amino acid oxidase (DAAO) inhibitory activities with IC50 values ranging from 0.6 to 15 μM in vitro. SAR analysis revealed their binding modes with DAAO and provided an important clue for further design of highly potent DAAO inhibitors with novel structures.

KW - D-Amino acid oxidase

KW - DAAO

KW - DAAO inhibitors

KW - Quinoxaline-2,3-diones

UR - https://www.scopus.com/pages/publications/84939897594

U2 - 10.1007/s00044-014-1068-z

DO - 10.1007/s00044-014-1068-z

M3 - Article

AN - SCOPUS:84939897594

SN - 1054-2523

VL - 23

SP - 4977

EP - 4989

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 11

ER -

Quinoxaline-2,3-diones: Potential D-amino acid oxidase (DAAO) inhibitors

Abstract

Keywords

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